CAPNS1

Calpain, small subunit 1
PDB rendering based on 1aj5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1aj5​, 1alv​, 1alw​, 1df0​, 1dvi​, 1kfu​, 1kfx​, 1np8​, 1nx0​, 1nx1​, 1nx2​, 1nx3​, 1u5i​
Identifiers
Symbols	CAPNS1 ; CANP; 30K; CALPAIN4; CANPS; CAPN4; CDPS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1327
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calpain, small subunit 1, also known as CAPNS1, is a human gene.

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.

Further reading

• Suzuki K, Sorimachi H, Yoshizawa T; et al. (1996). "Calpain: novel family members, activation, and physiologic function". Biol. Chem. Hoppe-Seyler. 376 (9): 523–9. PMID 8561910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tidball JG, Spencer MJ (2000). "Calpains and muscular dystrophies". Int. J. Biochem. Cell Biol. 32 (1): 1–5. PMID 10661889.
• Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in molecular medicine. 7 (8): 355–62. PMID 11516996.
• Reverter D, Sorimachi H, Bode W (2001). "The structure of calcium-free human m-calpain: implications for calcium activation and function". Trends Cardiovasc. Med. 11 (6): 222–9. PMID 11673052.CS1 maint: Multiple names: authors list (link)
• Banik NL, DeVries GH, Neuberger T; et al. (1991). "Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP". J. Neurosci. Res. 29 (3): 346–54. doi:10.1002/jnr.490290310. PMID 1656060.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohno S, Minoshima S, Kudoh J; et al. (1990). "Four genes for the calpain family locate on four distinct human chromosomes". Cytogenet. Cell Genet. 53 (4): 225–9. PMID 2209092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohno S, Emori Y, Suzuki K (1986). "Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease". Nucleic Acids Res. 14 (13): 5559. PMID 3016651.CS1 maint: Multiple names: authors list (link)
• Miyake S, Emori Y, Suzuki K (1987). "Gene organization of the small subunit of human calcium-activated neutral protease". Nucleic Acids Res. 14 (22): 8805–17. PMID 3024120.CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang W, Lane RD, Mellgren RL (1996). "The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells". J. Biol. Chem. 271 (31): 18825–30. PMID 8702541.CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Noguchi M, Sarin A, Aman MJ; et al. (1997). "Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11534–9. PMID 9326644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strobl S, Fernandez-Catalan C, Braun M; et al. (2000). "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 588–92. PMID 10639123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masumoto H, Nakagawa K, Irie S; et al. (2000). "Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain". Acta Crystallogr. D Biol. Crystallogr. 56 (Pt 1): 73–5. PMID 10666632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reverter D, Strobl S, Fernandez-Catalan C; et al. (2002). "Structural basis for possible calcium-induced activation mechanisms of calpains". Biol. Chem. 382 (5): 753–66. PMID 11517928.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)