C8 complex
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| complement component 8, alpha polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8A |
| Entrez | 731 |
| HUGO | 1352 |
| OMIM | 120950 |
| RefSeq | NM_000562 |
| UniProt | P07357 |
| Other data | |
| Locus | Chr. 1 p36.2-22.1 |
| complement component 8, beta polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8B |
| Entrez | 732 |
| HUGO | 1353 |
| OMIM | 1209660 |
| RefSeq | NM_000066 |
| UniProt | P073o58 |
| Other data | |
| Locus | Chr. 1 p36.2-22.1 |
| complement component 8, gamma polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8G |
| Entrez | 733 |
| HUGO | 1354 |
| OMIM | 120930 |
| RefSeq | NM_000606 |
| UniProt | P07360 |
| Other data | |
| Locus | Chr. 9 q34.3 |
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol
External links
- Complement+C8 at the US National Library of Medicine Medical Subject Headings (MeSH)
The crystal structure is now in the PDB, PDB ID 3OJY.
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