Butyrylcholinesterase

Butyrylcholinesterase
PDB rendering based on 1p0i.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1p0i​, 1p0m​, 1p0p​, 1p0q​, 1xlu​, 1xlv​, 1xlw​, 2j4c​
Identifiers
Symbols	BCHE ; CHE1; E1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20065
EC number	3.1.1.8
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Butyrylcholinesterase, also known as BCHE, is a human gene. Butyrylcholinesterase is also called serum cholinesterase. It is very similar to the neuronal acetylcholinesterase. Butyrylcholine is a synthetic compound and does not occur in the body naturally. It is used as a tool to distinguish between acetyl- and butyrylcholinesterase.

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

See also

Cholinesterase enzyme

Further reading

• Lockridge O (1989). "Structure of human serum cholinesterase". Bioessays. 9 (4): 125–8. doi:10.1002/bies.950090406. PMID 3067729.
• Allderdice PW, Gardner HA, Galutira D; et al. (1992). "The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26". Genomics. 11 (2): 452–4. PMID 1769657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gaughan G, Park H, Priddle J; et al. (1992). "Refinement of the localization of human butyrylcholinesterase to chromosome 3q26.1-q26.2 using a PCR-derived probe". Genomics. 11 (2): 455–8. PMID 1769658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arpagaus M, Kott M, Vatsis KP; et al. (1990). "Structure of the gene for human butyrylcholinesterase. Evidence for a single copy". Biochemistry. 29 (1): 124–31. PMID 2322535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nogueira CP, McGuire MC, Graeser C; et al. (1990). "Identification of a frameshift mutation responsible for the silent phenotype of human serum cholinesterase, Gly 117 (GGT----GGAG)". Am. J. Hum. Genet. 46 (5): 934–42. PMID 2339692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McGuire MC, Nogueira CP, Bartels CF; et al. (1989). "Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 953–7. PMID 2915989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prody CA, Zevin-Sonkin D, Gnatt A; et al. (1987). "Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues". Proc. Natl. Acad. Sci. U.S.A. 84 (11): 3555–9. PMID 3035536.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lockridge O, Adkins S, La Du BN (1987). "Location of disulfide bonds within the sequence of human serum cholinesterase". J. Biol. Chem. 262 (27): 12945–52. PMID 3115973.CS1 maint: Multiple names: authors list (link)
• McTiernan C, Adkins S, Chatonnet A; et al. (1987). "Brain cDNA clone for human cholinesterase". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6682–6. PMID 3477799.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lockridge O, Bartels CF, Vaughan TA; et al. (1987). "Complete amino acid sequence of human serum cholinesterase". J. Biol. Chem. 262 (2): 549–57. PMID 3542989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jbilo O, Toutant JP, Vatsis KP; et al. (1994). "Promoter and transcription start site of human and rabbit butyrylcholinesterase genes". J. Biol. Chem. 269 (33): 20829–37. PMID 8063698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mattes C, Bradley R, Slaughter E, Browne S (1996). "Cocaine and butyrylcholinesterase (BChE): determination of enzymatic parameters". Life Sci. 58 (13): PL257–61. PMID 8622553.CS1 maint: Multiple names: authors list (link)
• Iida S, Kinoshita M, Fujii H; et al. (1996). "Mutations of human butyrylcholinesterase gene in a family with hypocholinesterasemia". Hum. Mutat. 6 (4): 349–51. doi:10.1002/humu.1380060411. PMID 8680411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamendulis LM, Brzezinski MR, Pindel EV; et al. (1996). "Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases". J. Pharmacol. Exp. Ther. 279 (2): 713–7. PMID 8930175.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hidaka K, Iuchi I, Tomita M; et al. (1998). "Genetic analysis of a Japanese patient with butyrylcholinesterase deficiency". Ann. Hum. Genet. 61 (Pt 6): 491–6. doi:10.1046/j.1469-1809.1997.6160491.x. PMID 9543549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Browne SP, Slaughter EA, Couch RA; et al. (1998). "The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma". Biopharmaceutics & drug disposition. 19 (5): 309–14. PMID 9673783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Altamirano CV, Lockridge O (1999). "Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers". Biochemistry. 38 (40): 13414–22. PMID 10529218.
• Darvesh S, Kumar R, Roberts S; et al. (2002). "Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin". Cell. Mol. Neurobiol. 21 (3): 285–96. PMID 11569538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barta C, Sasvari-Szekely M, Devai A; et al. (2002). "Analysis of mutations in the plasma cholinesterase gene of patients with a history of prolonged neuromuscular block during anesthesia". Mol. Genet. Metab. 74 (4): 484–8. doi:10.1006/mgme.2001.3251. PMID 11749053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)