Bunaftine: Difference between revisions

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__NOTOC__
{{Drugbox
{{drugbox |
| verifiedrevid = 447613606
| IUPAC_name = ''N''-butyl-''N''-(2-diethylaminoethyl)naphthalene-1-<br>carboxamide
| IUPAC_name = ''N''-[2-(diethylamino)ethyl]-''N''-propylnaphthalene-1-carboxamide
| image = Bunaftine_svg.png
| image = Bunaftine_svg.png
<!--Clinical data-->
| tradename = 
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK = <!-- GSL        / P      / POM / CD -->
| legal_US = <!-- OTC                  / Rx-only  -->
| legal_status = 
| routes_of_administration = 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 32421-46-8
| CAS_number = 32421-46-8
| ATC_prefix = C01
| ATC_prefix = C01
| ATC_suffix = BD03
| ATC_suffix = BD03
| PubChem = 36131
| PubChem = 36131
| DrugBank =  
| ChEMBL = 2104200
| C = 21 | H = 30 | N = 2 | O = 1  
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 33233
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = GH09PRQ3FU
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07428
 
<!--Chemical data-->
| C=21 | H=30 | N=2 | O=1  
| molecular_weight = 326.476 g/mol
| molecular_weight = 326.476 g/mol
| bioavailability =  
| smiles = O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12
| protein_bound =  
| InChI = 1/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3
| metabolism =  
| InChIKey = WWGZXRYELYWJBD-UHFFFAOYAK
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =
| StdInChI = 1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US =  <!-- A / B            / C / D / X -->
| StdInChIKey = WWGZXRYELYWJBD-UHFFFAOYSA-N
| pregnancy_category = 
| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK =      <!-- GSL        / P      / POM / CD -->
| legal_US =      <!-- OTC                  / Rx-only  -->
| legal_status =  
| routes_of_administration =  
}}
}}
__NOTOC__
{{SI}}
{{CMG}}
{{CMG}}


==Overview==
'''Bunaftine''' is an [[antiarrhythmic agent]].<ref name="pmid6876382">{{cite journal |author=Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M |title=Intropic effects of several antiarrhythmic drugs |journal=Jpn Heart J |volume=24 |issue=3 |pages=377–90 |date=May 1983 |pmid=6876382 |doi= |url=}}</ref> It is classified in [[class III antiarrhythmic|class III]].<ref name="pmid328029">{{cite journal |author=Fenici R, Marchei M, Bellocci F, Zecchi P |title=Effect of bunaphtine on right atrial repolarisation in man |journal=Br Heart J |volume=39 |issue=7 |pages=787–94 |date=July 1977 |pmid=328029 |pmc=483317 |doi= 10.1136/hrt.39.7.787|url=http://heart.bmj.com/cgi/pmidlookup?view=long&pmid=328029}}</ref>


It is also spelled "bunaphtine".<ref name="pmid7436628">{{cite journal |author=Tamargo J |title=Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers |journal=Arch Int Pharmacodyn Ther |volume=246 |issue=2 |pages=224–36 |date=August 1980 |pmid=7436628 |doi= |url=}}</ref>


 
==References==
'''Bunaftine''' is a class III [[antiarrhythmic agent]].
{{reflist|2}}


{{Antiarrhythmic agents}}
{{Antiarrhythmic agents}}


[[Category:Antiarrhythmic agents]]
[[Category:Antiarrhythmic agents]]
[[Category:Drugs]]
[[Category:Cardiovascular Drugs]]
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Latest revision as of 22:24, 23 July 2014

Bunaftine
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC21H30N2O
Molar mass326.476 g/mol
3D model (JSmol)
  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bunaftine is an antiarrhythmic agent.[1] It is classified in class III.[2]

It is also spelled "bunaphtine".[3]

References

  1. Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. PMID 6876382.
  2. Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317. PMID 328029.
  3. Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628.

Template:Antiarrhythmic agents