Brain tumor medical therapy

Jump to navigation Jump to search

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Brain tumor Microchapters

Patient Information

Overview

Classification

Adult brain tumors
Glioblastoma multiforme
Oligodendroglioma
Meningioma
Hemangioblastoma
Pituitary adenoma
Schwannoma
Primary CNS lymphoma
Childhood brain tumors
Pilocytic astrocytoma
Medulloblastoma
Ependymoma
Craniopharyngioma
Pinealoma
Metastasis
Lung cancer
Breast cancer
Melanoma
Gastrointestinal tract cancer
Renal cell carcinoma
Osteoblastoma
Head and neck cancer
Neuroblastoma
Lymphoma
Prostate cancer

Causes

Differentiating Brain Tumor from other Diseases

Overview

Although there is no generally accepted therapeutic management for primary brain tumors, a surgical attempt at tumor removal or at least cytoreduction (that is, removal of as much tumor as possible, in order to reduce the number of tumor cells available for proliferation) is considered in most cases[1]. However, due to the infiltrative nature of these lesions, tumor recurrence, even following an apparently complete surgical removal, is not uncommon. Postoperative radiotherapy and chemotherapy are integral parts of the therapeutic standard for malignant tumors. Radiotherapy may also be administered in cases of "low-grade" gliomas, when a significant tumor burden reduction could not be achieved surgically.

Chemotherapy may be used with surgery or radiation treatment.

Medical Therapy

Some drugs that are used to treat brain cancer are:

  • Lomustine- FDA approved - used in patients who have already had surgery or radiation therapy
  • Temozolomide- FDA approved - used in adults for the treatment of Anaplatic astrocytomas and Glioblastoma multiforme

Other medications used to treat primary brain tumors in children may include:

  • Corticosteroids, such as dexamethasone, to reduce brain swelling
  • Medicines such as urea or mannitol to reduce brain swelling and pressure
  • Anticonvulsants, such as evetiracetam (Keppra), to reduce seizures
  • Pain medications
  • Antacids or histamine blockers to control

Contraindicated medications

Cerebral neoplasm is considered an absolute contraindication to the use of the following medications:


References

  1. Nakamura M, Konishi N, Tsunoda S, Nakase H, Tsuzuki T, Aoki H, Sakitani H, Inui T, Sakaki T. Analysis of prognostic and survival factors related to treatment of low-grade astrocytomas in adults. Oncology 2000;58:108-16. PMID 10705237.

Template:WH Template:WS