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'''Bepridil''' (trade name '''Vascor''') is a [[calcium channel blocker]] once used to treat [[Angina pectoris|angina]]. It is no longer sold in the United States.
'''Bepridil''' (trade name '''Vascor''') is a [[calcium channel blocker]] once used to treat [[Angina pectoris|angina]]. It is no longer sold in the United States.
It is nonselective.<ref name="pmid7565636">{{cite journal |author=Bezprozvanny I, Tsien RW |title=Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967) |journal=Mol. Pharmacol. |volume=48 |issue=3 |pages=540–9 |date=September 1995 |pmid=7565636 |doi= |url=http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7565636}}</ref>
It has been discussed as a possible option in the treatment of [[atrial fibrillation]].<ref name="pmid18441448">{{cite journal |author=Imai S, Saito F, Takase H, ''et al.'' |title=Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm |journal=Circ. J. |volume=72 |issue=5 |pages=709–15 |date=May 2008 |pmid=18441448 |doi= 10.1253/circj.72.709|url=https://www.jstage.jst.go.jp/article/circj/72/5/72_5_709/_pdf |format=}}</ref>
It has been implicated in causing ventricular arrhythmia ([[Torsade de pointes]]).


==External links==
==External links==
* {{MedlinePlusDrugInfo|medmaster|a697050}}
* {{MedlinePlusDrugInfo|medmaster|a697050}}
{{Reflist|2}}


{{Calcium channel blockers}}
{{Calcium channel blockers}}


[[Category:Calcium channel blockers]]
[[Category:Calcium channel blockers]]
[[Category:Pyrrolidines]]
[[Category:Amines]]
[[Category:Ethers]]
[[Category:Cardiovascular Drugs]]


[[Category:Drugs]]
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Revision as of 18:52, 23 July 2014

Bepridil
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration		Oral
ATC code
Pharmacokinetic data
BioavailabilityWell absorbed
Protein binding99%
MetabolismHepatic, CYP3A4-mediated
Elimination half-life42 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC24H34N2O
Molar mass421.02 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Sheng Shi, M.D. [2]

Bepridil (trade name Vascor) is a calcium channel blocker once used to treat angina. It is no longer sold in the United States.

It is nonselective.[1]

It has been discussed as a possible option in the treatment of atrial fibrillation.[2]

It has been implicated in causing ventricular arrhythmia (Torsade de pointes).


External links

  1. ↑ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636.
  2. ↑ Imai S, Saito F, Takase H; et al. (May 2008). "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm". Circ. J. 72 (5): 709–15. doi:10.1253/circj.72.709. PMID 18441448.

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