Back pain pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S[2]

Overview

Pathophysiology

Physiology

The normal physiology of [name of process] can be understood as follows:

Pathogenesis

Type of back pain Pathophysiology
Inflammatory Inflammation of joints (sacroiliitis), inflammation of enthesis (spondyloarthritis)
Mechanical Trauma, muscle sprain, extra weight on muscles (pregnancy, heavy lifting),
Oncologic Lytic lesions in spine, nerve compression due to mass effect, pathologic fracture due to weakened bone
Degenerative Cartilage degradation and bone remodeling decreases elasticity and causes pain , fractures can also occur due to osteoporosis,
Infectious Infection involving spine, disc, joints, abscess formation.

Genetics

[Disease name] is transmitted in [mode of genetic transmission] pattern.

OR

Genes involved in the pathogenesis of [disease name] include:

  • [Gene1]
  • [Gene2]
  • [Gene3]

OR

The development of [disease name] is the result of multiple genetic mutations such as:

  • [Mutation 1]
  • [Mutation 2]
  • [Mutation 3]

Associated Conditions

Conditions associated with [disease name] include:

  • [Condition 1]
  • [Condition 2]
  • [Condition 3]

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

References

  1. Patrick N, Emanski E, Knaub MA (2014). "Acute and chronic low back pain". Med Clin North Am. 98 (4): 777–89, xii. doi:10.1016/j.mcna.2014.03.005. PMID 24994051.