BUB3

BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
Identifiers
Symbols	BUB3 ; BUB3L; hBUB3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3470
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast), also known as BUB3, is a human gene.

This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Taylor SS, Ha E, McKeon F (1998). "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase". J. Cell Biol. 142 (1): 1–11. PMID 9660858.CS1 maint: Multiple names: authors list (link)
• Cahill DP, da Costa LT, Carson-Walter EB; et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kwon TK, Hawkins AL, Griffin CA, Gabrielson E (2000). "Assignment of BUB3 to human chromosome band 10q26 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 202–3. PMID 10828586.CS1 maint: Multiple names: authors list (link)
• Saffery R, Irvine DV, Griffiths B; et al. (2001). "Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes". Hum. Genet. 107 (4): 376–84. PMID 11129339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaplan KB, Burds AA, Swedlow JR; et al. (2001). "A role for the Adenomatous Polyposis Coli protein in chromosome segregation". Nat. Cell Biol. 3 (4): 429–32. doi:10.1038/35070123. PMID 11283619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sudakin V, Chan GK, Yen TJ (2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5): 925–36. doi:10.1083/jcb.200102093. PMID 11535616.CS1 maint: Multiple names: authors list (link)
• Saxena A, Saffery R, Wong LH; et al. (2002). "Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated". J. Biol. Chem. 277 (30): 26921–6. doi:10.1074/jbc.M200620200. PMID 12011073.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saxena A, Wong LH, Kalitsis P; et al. (2003). "Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc". Hum. Mol. Genet. 11 (19): 2319–29. PMID 12217960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baek WK, Park JW, Lim JH; et al. (2003). "Molecular cloning and characterization of the human budding uninhibited by benomyl (BUB3) promoter". Gene. 295 (1): 117–23. PMID 12242018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. PMID 12762840.CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoon YM, Baek KH, Jeong SJ; et al. (2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett. 575 (1–3): 23–9. doi:10.1016/j.febslet.2004.07.089. PMID 15388328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tang Z, Shu H, Oncel D; et al. (2004). "Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint". Mol. Cell. 16 (3): 387–97. doi:10.1016/j.molcel.2004.09.031. PMID 15525512.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mendoza S, David H, Gaylord GM, Miller CW (2005). "Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes". Cancer Genet. Cytogenet. 158 (2): 142–7. doi:10.1016/j.cancergencyto.2004.08.035. PMID 15796961.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lo KW, Kogoy JM, Pfister KK (2007). "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3". J. Biol. Chem. 282 (15): 11205–12. doi:10.1074/jbc.M611279200. PMID 17289665.CS1 maint: Multiple names: authors list (link)