BICD1: Difference between revisions

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Identifiers
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Orthologs
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Latest revision as of 02:35, 30 August 2017

Protein bicaudal D homolog 1 is a protein that in humans is encoded by the BICD1 gene.^[1]^[2]

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.^[2]

Interactions

BICD1 has been shown to interact with RAB6A.^[3]^[4]

References

↑ Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.
↑ ^2.0 ^2.1 "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".
↑ Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177.
↑ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383.

External links

Human BICD1 genome location and BICD1 gene details page in the UCSC Genome Browser.

Barr FA, Short B (Aug 2003). "Golgins in the structure and dynamics of the Golgi apparatus". Current Opinion in Cell Biology. 15 (4): 405–13. doi:10.1016/S0955-0674(03)00054-1. PMID 12892780. Check date values in: |year= / |date= mismatch (help)
Claussen M, Suter B (Nov 2005). "BicD-dependent localization processes: from Drosophilia development to human cell biology". Annals of Anatomy - Anatomischer Anzeiger. 187 (5–6): 539–53. doi:10.1016/j.aanat.2005.07.004. PMID 16320833. Check date values in: |year= / |date= mismatch (help)
Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P (Sep 1995). "Isolation and regional assignment of human chromosome 12p cDNAs". Genomics. 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100. Check date values in: |year= / |date= mismatch (help)
Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. Check date values in: |year= / |date= mismatch (help)
Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. Check date values in: |year= / |date= mismatch (help)
Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Fuchs E, Short B, Barr FA (2006). "Assay and properties of rab6 interaction with dynein-dynactin complexes". Methods in Enzymology. 403: 607–18. doi:10.1016/S0076-6879(05)03053-3. PMID 16473624.
Moorhead AR, Rzomp KA, Scidmore MA (Feb 2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner". Infection and Immunity. 75 (2): 781–91. doi:10.1128/IAI.01447-06. PMC 1828475. PMID 17101644.
Fumoto K, Hoogenraad CC, Kikuchi A (Dec 2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". The EMBO Journal. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249. Check date values in: |year= / |date= mismatch (help)
Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (Oct 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[pmid9367685-1] Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.

[entrez-2] 2.0 ^2.1 "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".

[pmid12401177-3] Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177.

[pmid12447383-4] Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Protein bicaudal D homolog 1''' is a [[protein]] that in humans is encoded by the ''BICD1'' [[gene]].<ref name="pmid9367685">{{cite journal | vauthors = Baens M, Marynen P | title = A human homologue (BICD1) of the Drosophila bicaudal-D gene | journal = Genomics | volume = 45 | issue = 3 | pages = 601–6 | date = Nov 1997 | pmid = 9367685 | pmc =  | doi = 10.1006/geno.1997.4971 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=636| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Bicaudal D homolog 1 (Drosophila)
- | HGNCid = 1049
- | Symbol = BICD1
- | AltSymbols =; BICD
- | OMIM = 602204
- | ECnumber =
- | Homologene = 37518
- | MGIid = 1101760
- | GeneAtlas_image1 = PBB_GE_BICD1_204741_at_tn.png
- | Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}}
- | Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
- | Process = {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0008298 |text = intracellular mRNA localization}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 636
-    | Hs_Ensembl = ENSG00000151746
-    | Hs_RefseqProtein = NP_001003398
-    | Hs_RefseqmRNA = NM_001003398
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 32151452
-    | Hs_GenLoc_end = 32422408
-    | Hs_Uniprot = Q96G01
-    | Mm_EntrezGene = 12121
-    | Mm_Ensembl = ENSMUSG00000003452
-    | Mm_RefseqmRNA = NM_009753
-    | Mm_RefseqProtein = NP_033883
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 149366599
-    | Mm_GenLoc_end = 149476286
-    | Mm_Uniprot = Q5DTM3
-  }}
-}}
-'''Bicaudal D homolog 1 (Drosophila)''', also known as '''BICD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=636| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=636| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+BICD1 has been shown to [[Protein-protein interaction|interact]] with [[RAB6A]].<ref name=pmid12401177>{{cite journal | vauthors = Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA | title = The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes | journal = Current Biology | volume = 12 | issue = 20 | pages = 1792–5 | date = Oct 2002 | pmid = 12401177 | doi = 10.1016/S0960-9822(02)01221-6 }}</ref><ref name=pmid12447383>{{cite journal | vauthors = Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC | title = Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex | journal = Nature Cell Biology | volume = 4 | issue = 12 | pages = 986–92 | date = Dec 2002 | pmid = 12447383 | doi = 10.1038/ncb891 }}</ref>
+== References ==
+{{reflist}}
+==External links==
+* {{UCSC gene info|BICD1}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Barr FA, Short B | title = Golgins in the structure and dynamics of the Golgi apparatus | journal = Current Opinion in Cell Biology | volume = 15 | issue = 4 | pages = 405–13 | year = 2004 | date = Aug 2003 | pmid = 12892780 | doi = 10.1016/S0955-0674(03)00054-1 }}
-| citations =
+* {{cite journal | vauthors = Claussen M, Suter B | title = BicD-dependent localization processes: from Drosophilia development to human cell biology | journal = Annals of Anatomy - Anatomischer Anzeiger | volume = 187 | issue = 5-6 | pages = 539–53 | year = 2006 | date = Nov 2005 | pmid = 16320833 | doi = 10.1016/j.aanat.2005.07.004 }}
-*{{cite journal  | author=Barr FA, Short B |title=Golgins in the structure and dynamics of the Golgi apparatus. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 4 |pages= 405-13 |year= 2004 |pmid= 12892780 |doi=  }}
+* {{cite journal | vauthors = Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P | title = Isolation and regional assignment of human chromosome 12p cDNAs | journal = Genomics | volume = 29 | issue = 1 | pages = 44–52 | year = 1996 | date = Sep 1995 | pmid = 8530100 | doi = 10.1006/geno.1995.1213 }}
-*{{cite journal  | author=Claussen M, Suter B |title=BicD-dependent localization processes: from Drosophilia development to human cell biology. |journal=Ann. Anat. |volume=187 |issue= 5-6 |pages= 539-53 |year= 2006 |pmid= 16320833 |doi=  }}
+* {{cite journal | vauthors = Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA | title = The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes | journal = Current Biology | volume = 12 | issue = 20 | pages = 1792–5 | year = 2003 | date = Oct 2002 | pmid = 12401177 | doi = 10.1016/S0960-9822(02)01221-6 }}
-*{{cite journal  | author=Baens M, Aerssens J, van Zand K, ''et al.'' |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44-52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213 }}
+* {{cite journal | vauthors = Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC | title = Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex | journal = Nature Cell Biology | volume = 4 | issue = 12 | pages = 986–92 | year = 2003 | date = Dec 2002 | pmid = 12447383 | doi = 10.1038/ncb891 }}
-*{{cite journal  | author=Baens M, Marynen P |title=A human homologue (BICD1) of the Drosophila bicaudal-D gene. |journal=Genomics |volume=45 |issue= 3 |pages= 601-6 |year= 1998 |pmid= 9367685 |doi= 10.1006/geno.1997.4971 }}
+* {{cite journal | vauthors = Tomsig JL, Snyder SL, Creutz CE | title = Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif | journal = The Journal of Biological Chemistry | volume = 278 | issue = 12 | pages = 10048–54  | date = Mar 2003 | pmid = 12522145 | doi = 10.1074/jbc.M212632200 }}
-*{{cite journal  | author=Short B, Preisinger C, Schaletzky J, ''et al.'' |title=The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes. |journal=Curr. Biol. |volume=12 |issue= 20 |pages= 1792-5 |year= 2003 |pmid= 12401177 |doi=  }}
+* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65  | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
-*{{cite journal  | author=Matanis T, Akhmanova A, Wulf P, ''et al.'' |title=Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 986-92 |year= 2003 |pmid= 12447383 |doi= 10.1038/ncb891 }}
+* {{cite journal | vauthors = Fuchs E, Short B, Barr FA | title = Assay and properties of rab6 interaction with dynein-dynactin complexes | journal = Methods in Enzymology | volume = 403 | issue =  | pages = 607–18 | year = 2006 | pmid = 16473624 | doi = 10.1016/S0076-6879(05)03053-3 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Moorhead AR, Rzomp KA, Scidmore MA | title = The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner | journal = Infection and Immunity | volume = 75 | issue = 2 | pages = 781–91  | date = Feb 2007 | pmid = 17101644 | pmc = 1828475 | doi = 10.1128/IAI.01447-06 }}
-*{{cite journal  | author=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048-54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200 }}
+* {{cite journal | vauthors = Fumoto K, Hoogenraad CC, Kikuchi A | title = GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome | journal = The EMBO Journal | volume = 25 | issue = 24 | pages = 5670–82 | year = 2007 | date = Dec 2006 | pmid = 17139249 | pmc = 1698904 | doi = 10.1038/sj.emboj.7601459 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA | title = A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells | journal = Experimental Cell Research | volume = 313 | issue = 16 | pages = 3408–20  | date = Oct 2007 | pmid = 17707369 | doi = 10.1016/j.yexcr.2007.05.032 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
-*{{cite journal  | author=Fuchs E, Short B, Barr FA |title=Assay and properties of rab6 interaction with dynein-dynactin complexes. |journal=Meth. Enzymol. |volume=403 |issue=  |pages= 607-18 |year= 2006 |pmid= 16473624 |doi= 10.1016/S0076-6879(05)03053-3 }}
-*{{cite journal  | author=Moorhead AR, Rzomp KA, Scidmore MA |title=The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner. |journal=Infect. Immun. |volume=75 |issue= 2 |pages= 781-91 |year= 2007 |pmid= 17101644 |doi= 10.1128/IAI.01447-06 }}
-*{{cite journal  | author=Fumoto K, Hoogenraad CC, Kikuchi A |title=GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. |journal=EMBO J. |volume=25 |issue= 24 |pages= 5670-82 |year= 2007 |pmid= 17139249 |doi= 10.1038/sj.emboj.7601459 }}
-*{{cite journal  | author=Wanschers BF, van de Vorstenbosch R, Schlager MA, ''et al.'' |title=A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3408-20 |year= 2007 |pmid= 17707369 |doi= 10.1016/j.yexcr.2007.05.032 }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{gene-12-stub}}

BICD1: Difference between revisions

Latest revision as of 02:35, 30 August 2017

Contents

Function

Interactions

References

External links

Further reading

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