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{{Avian influenza}}
{{Avian influenza}}
==Overview==
==Overview==
[[Avian influenza]]<nowiki/>was first described by Perroncito in 1878 in northern Italy following an outbreak of contagious disease of poultry. The first major human influenza (influenza A H1N1) pandemic was reported in 1918. The first influenza A H5N1 virus infection in humans was described in 1997 in Hong Kong, where 18 cases were documented (including 6 deaths). The first human-to-human transmission of avian influenza infection was described in 2003 during several outbreaks in Southeast and Central Asia.
==Historical Perspective==
==Historical Perspective==
*Avian influenza was first described in  
*[[Avian influenza]] was first described by Perroncito in 1878 in northern Italy following an outbreak of contagious disease of poultry. In 1984 and 1901, subsequent outbreaks were reported in Italy, Germany, Austria, Belgium, and France.  
 
* All viral forms were considered highly pathological avian influenza (HPAI) forms of H7 subtype until mid-1950s. After that, other H subtypes were subsequently isolated. In 1960, a new less virulent "N" subtype of avian influenza was isolated in Germany.  
 
* The first major human influenza (influenza A H1N1) pandemic was reported in 1918. The infleunza was an avian-descended virus that underwent adaptive mutations of unknown mechanisms.  
'''OFFLU''' is the '''O'''IE/'''F'''AO Network of Expertise on Avian In'''flu'''enza. "In April 2005, the [[OIE]] and [[FAO]] created and endorsed a joint network of expertise on [[Avian influenza]] for the benefit of Member Countries. The objectives of OFFLU are :
* The first influenza A H5N1 virus infection in humans was described in 1997 in Hong Kong, where 18 cases were documented (including 6 deaths).  
# To exchange scientific data and biological materials (including virus strains) within the network, and to share such information with the wider scientific community.
* In 2003, the largest non-H5N1 outbreak occurred in Netherlands, where 89 cases were documented (including 1 death). It is hypothesized that during the Netherlands outbreak, the first human-to-human transmission may have occurred.  
# To offer technical advice and veterinary expertise to Member Countries to assist in the diagnosis, surveillance and control of avian influenza.
* In 2003, human-to-human transmission of avian influenza was first reported during several influenza A H5N1 outbreaks in Southeast and Central Asia.
# To collaborate with the WHO influenza network on issues relating to the animal-human interface.
* It has been speculated that following genetic mutations, the avian influenza virus may be evolving into more virulent and fatal forms, with increased rates of severe clinical manifestations.  
# To highlight avian influenza research needs, promote their development and ensure co-ordination."<ref> [http://www.offlu.net/ OFFLU home page]</ref>
 
In February 2006, "OFFLU launched a campaign for openness when Dr. Ilaria Capua of Italy, chair of the network's Scientific Committee, published sequence data on H5N1 strains from Nigeria and Italy and urged 50 colleagues around the world to share their data. In March, the OFFLU Scientific Committee decided "to put new emphasis on the need for further collection, characterization, and exchange" of avian flu viruses and for expansion of sequence data, the FAO reported. At about the same time, Capua and four OFFLU colleagues wrote a letter to the journal Science promising to make H5N1 samples available for sequencing."<ref> [http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/aug0306sharing.html CIDRAP] article ''Indonesia, FAO, OIE pledge to publish H5N1 data'' published August 3, 2006</ref>


==Sources==
==Sources==
<references/>
<references />


==Further reading==
==Further reading==

Revision as of 20:50, 22 April 2015

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Overview

Avian influenzawas first described by Perroncito in 1878 in northern Italy following an outbreak of contagious disease of poultry. The first major human influenza (influenza A H1N1) pandemic was reported in 1918. The first influenza A H5N1 virus infection in humans was described in 1997 in Hong Kong, where 18 cases were documented (including 6 deaths). The first human-to-human transmission of avian influenza infection was described in 2003 during several outbreaks in Southeast and Central Asia.

Historical Perspective

  • Avian influenza was first described by Perroncito in 1878 in northern Italy following an outbreak of contagious disease of poultry. In 1984 and 1901, subsequent outbreaks were reported in Italy, Germany, Austria, Belgium, and France.
  • All viral forms were considered highly pathological avian influenza (HPAI) forms of H7 subtype until mid-1950s. After that, other H subtypes were subsequently isolated. In 1960, a new less virulent "N" subtype of avian influenza was isolated in Germany.
  • The first major human influenza (influenza A H1N1) pandemic was reported in 1918. The infleunza was an avian-descended virus that underwent adaptive mutations of unknown mechanisms.
  • The first influenza A H5N1 virus infection in humans was described in 1997 in Hong Kong, where 18 cases were documented (including 6 deaths).
  • In 2003, the largest non-H5N1 outbreak occurred in Netherlands, where 89 cases were documented (including 1 death). It is hypothesized that during the Netherlands outbreak, the first human-to-human transmission may have occurred.
  • In 2003, human-to-human transmission of avian influenza was first reported during several influenza A H5N1 outbreaks in Southeast and Central Asia.
  • It has been speculated that following genetic mutations, the avian influenza virus may be evolving into more virulent and fatal forms, with increased rates of severe clinical manifestations.

Sources


Further reading

  • CDC article OFFLU Network on Avian Influenza detailing OFFLU "achievements and constraints to date and plans for the future".



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References

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