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ICD-10 R53
ICD-9 780.7

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List of terms related to Asthenia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Asthenia (Greek: ασθένεια, lit. lack of strength but also disease) is a medical term denoting a feeling of weakness without actual loss of strength.

Causes of asthenia

The condition is commonly seen in patients suffering from chronic fatigue syndrome, sleep disorders or chronic disorders of the heart, lungs or kidneys. Differentiating between asthenia and true muscular weakness is often difficult, and in time asthenia in chronic disorders is seen to progress into a primary weakness. Also a condition in which the body lacks or has lost strength either as a whole or in any of its parts. General asthenia occurs in many chronic wasting diseases, such as anemia and cancer, and is probably most marked in diseases of the adrenal gland. Asthenia may be limited to certain organs or systems of organs, as in asthenopia, characterized by ready fatiguability.

Common causes of asthenia

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Acamprosate calcium, Aprepitant, Bicalutamide, Busulfan, Cefaclor, Desmopressin, Docetaxel, Efavirenz, Enzalutamide, Eribulin, Eslicarbazepine acetate, Fluvoxamine,Fosfomycin, Fulvestrant, Interferon alfa-2b , Pegylated interferon alfa-2a, Irinotecan hydrochloride, Meropenem, Nabilone, Netupitant and palonosetron, Oxaprozin, Palbociclib, Panitumumab, Perampanel, Pilocarpine, Pyridostigmine, Ribavirin, Ritonavir, Sargramostim, Sunitinib, Temozolomide, Teniposide
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

See also


  • Adapted from: Hinshaw DB, Carnahan JM, Johnson DL. Depression, anxiety, and asthenia in advanced illness. J Am Coll Surg 2002;195:276.

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