Aspergillosis differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Haytham Allaham, M.D. [2]; Serge Korjian M.D.
Overview
Aspergillosis must be differentiated from other diseases that cause fever, chest pain, dyspnea, sinusitis, allergic symptoms, and elevated IgE concentrations. Differential diagnosis includes other infections (fungi, bacteria, viruses, and parasites), non-infectious pulmonary diseases (such as asthma, COPD, interstitial lung disease, bronchiectasis, and lung tumors), cardiac diseases (such as pericarditis, endocarditis, or myocarditis), facial diseases (such as infectious sinusitis, sinus tumor, or nasal polyps), systemic diseases (such as Hyper IgE syndrome, Churg-Strauss syndrome, granulomatosis with polyangiitis, Goodpasture's syndrome), congenital diseases (such as cystic fibrosis or ciliary dyskinesia), transplant-related complications (such as GVHD), diseases with cutaneous manifestations (such as eczema, scabies, deep vein thrombosis, cellulitis), and adverse drug reactions.
Diffential Diagnosis
Aspergillosis must be differentiated from other diseases that cause fever, chest pain, dyspnea, sinusitis, allergic symptoms, and elevated IgE concentrations. Differential diagnosis includes:
- Actinomycosis
- Acute Respiratory Distress Syndrome
- Aspiration (e.g. foreign body)
- Asthma
- Arteriovenous malformation
- Blastomycosis
- Bronchiectasis and mucoid impaction
- Bronchocentric granulomatosis
- Cellulitis
- Churg-Strauss syndrome
- Coccidiomycosis
- COPD exacerbation
- Cryptococcosis
- Ciliary dyskinesia
- Cystic fibrosis
- Deep vein thrombosis
- Drug - adverse reaction
- Eczema
- Endocarditis
- Eosinophilia
- Eosinophilic pneumonia
- Goodpasture's syndrome
- Granulocytopenia
- Granulomatosis with polyangiitis (Wegener's granulomatosis)
- Graft vs. host disease
- Heart failure
- Hemosiderosis
- Hemothorax
- Histoplasmosis
- Histiocytosis
- Hypereosinophilic syndrome
- Hypersensitivity Pneumonitis
- Hyper IgE syndrome (Job's syndrome)
- Impetigo
- Infectious sinusitis
- Interstitial lung disease
- Leishmaniasis
- Leproma (leprosy nodule)
- Leukemia
- Loffler's syndrome
- Lung Abscess
- Lung tumor (primary or metastatic)
- Lymphoma
- Malaria
- Mucormycosis
- Myeloproliferative disorder
- Myocardial abscess
- Myocarditis
- Nasopharyngeal polyp
- Nocardiosis
- Paracoccidioidomycosis
- Pericarditis
- Pneumonia
- Pneumothorax
- Pulmonary embolism
- Pulmonary eosinophilia
- Pulmonary arterial hypertension
- Sarcoidosis
- Scabies
- Scedosporiosis (pulmonary infection caused by the fungus Scedosporium)
- Sporotrichosis
- Sinus tumor
- Trauma
- Tuberculosis (including tuberculoma)
- Zygomycosis