Appendix cancer physical examination: Difference between revisions

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==Overview==
==Overview==
Patients with appendix cancer usually appear normal, pale or diaphoretic. If the patient with appendix cancer present with [[acute appendicitis]] which is quit common, abdominal tenderness, [[Rebound tenderness]], [[Abdominal guarding|abdominal guarding,]] [[Rovsing's sign|Rovsing's sign,]] as well as [[Psoas sign]] might be present. Around 5% of the patients with appendiceal carcinoid tumors might develop carcinoid syndrome. Common physical examination findings of carcinoid syndrome include dehydration due to diarrhea, tachycardia as well as facial flushing, right heart murmurs like TR murmur is quit common. In patients with carcinoid syndrome, the presence of dermatitis, diarrhea, and dementia on physical examination is highly suggestive of  of [[Pellagra]] disease.
Patients with [[Vermiform appendix|appendix]] [[cancer]] usually appear normal, [[Pallor|pale]] or [[Diaphoresis|diaphoretic]]. If the patient with appendix cancer present with [[acute appendicitis]] which is quite common, [[abdominal tenderness]], [[rebound tenderness]], [[Abdominal guarding|abdominal guarding,]] [[Rovsing's sign|Rovsing's sign,]] as well as [[Psoas sign]] might be present. Around 5% of the patients with appendiceal [[Carcinoid Tumor|carcinoid tumors]] might develop [[carcinoid syndrome]]. Common physical examination findings of [[carcinoid syndrome]] include [[dehydration]] due to [[diarrhea]], [[tachycardia]] as well as [[Flushing|facial flushing]], [[Heart murmurs|right heart murmurs]] like [[Tricuspid regurgitation|TR murmur]] is quit common. In patients with [[carcinoid syndrome]], the presence of [[dermatitis]], [[diarrhea]], and [[dementia]] on [[physical examination]] is highly suggestive of [[Pellagra]] disease.


==Physical Examination==
==Physical Examination==


*Physical examination of patients with appendix cancer is usually normal.
*[[Physical examination]] of patients with [[appendix cancer]] is usually normal.<ref name="WHO">Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref>
*If the patient with appendix cancer present with [[acute appendicitis]] which is quit common, abdominal tenderness, [[Rebound tenderness]], [[Abdominal guarding|abdominal guarding,]] [[Rovsing's sign|Rovsing's sign,]] as well as [[Psoas sign]] might be present.  
*If the patient with appendix cancer present with [[acute appendicitis]] which is quite common, [[abdominal tenderness]], [[rebound tenderness]], [[Abdominal guarding|abdominal guarding,]] [[Rovsing's sign|Rovsing's sign,]] as well as [[Psoas sign]] might be present. <ref>Hardin, M. Acute Appendicitis: Review and Update. ''Am Fam Physician".1999, Nov 1;60(7):2027-2034''</ref>
*Around 5% of the patients with appendiceal carcinoid tumors might develop carcinoid syndrome.
*Around 5% of the patients with appendiceal [[Carcinoid Tumor|carcinoid]] tumors might develop [[carcinoid syndrome]].
*Common physical examination findings of carcinoid syndrome include dehydration due to diarrhea, tachycardia as well as facial flushing, right heart murmurs like TR murmur is quit common.  
*Common physical examination findings of [[carcinoid syndrome]] include dehydration due to [[diarrhea]], [[tachycardia]] as well as facial [[flushing]], [[Heart murmur|right heart murmurs]] like [[Tricuspid regurgitation|TR]] [[Heart murmur|murmur]] is quit common.<ref name="ss">Signs and symptoms of carcinoid syndrome. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/patient/gi-carcinoid-treatment-pdq</ref>
*In patients with carcinoid syndrome, the presence of dermatitis, diarrhea, and dementia on physical examination is highly suggestive of  of [[Pellagra]] disease.
*In patients with [[carcinoid syndrome]], the presence of [[dermatitis]], [[diarrhea]], and [[dementia]] on physical examination is highly suggestive of [[Pellagra]] disease.<ref name="pmid14693013">Hegyi J, Schwartz RA, Hegyi V (2004) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=14693013 Pellagra: dermatitis, dementia, and diarrhea.] ''Int J Dermatol'' 43 (1):1-5. PMID: [https://pubmed.gov/14693013 14693013]</ref>


===Appearance of the Patient===
===Appearance of the Patient===
*Patients with appendix cancer usually appear normal but might be pale or diaphoretic, or even present with a facial flushing.  
*Patients with appendix cancer usually appear normal but might be pale or [[Diaphoresis|diaphoretic]], or even present with a facial [[flushing]].  


===Vital Signs===
===Vital Signs===


*Fever might be present in patients presenting with appendicitis.
*[[Fever]] might be present in patients presenting with appendicitis.
*[[Tachycardia]] is prevalent in patients with carcinoid syndrome as well as patients with appendicitis.
*[[Tachycardia]] is prevalent in patients with [[carcinoid syndrome]] as well as patients with [[appendicitis]].
*Tachypnea
*[[Tachypnea]]
*[[Hypertension]]
*[[Hypertension]]


===Skin===
===Skin===
* Skin examination of patients with appendix cancer is usually normal.
* Skin examination of patients with appendix cancer is usually normal.
* In the presence of carcinoid syndrome the following might be present:
* In the presence of [[carcinoid syndrome]] the following might be present:
**[[Flushing]]  
**[[Flushing]]  
** [[Hirsutism]]
** [[Hirsutism]]
** [[Pallor]]
** [[Pallor]]
** [[Dermatitis]] in the presence of [[Pellagra]]


===HEENT===
===HEENT===
* HEENT examination of patients with appendix cancer is usually normal.
* HEENT examination of patients with appendix cancer is usually normal.
* [[Glossitis]] may be suggestive of [[Pellagra]].
===Neck===
===Neck===
* Neck examination of patients with appendiceal cancer is usually normal.
* [[Neck]] examination of patients with appendiceal cancer is usually normal.
* [[Lymphadenopathy|Cervical lymphadenopathy]] might be present.
* [[Lymphadenopathy|Cervical lymphadenopathy]] might be present.
===Lungs===
===Lungs===
* Pulmonary examination of patients with appendix cancer is usually normal.
* [[Lung|Pulmonary]] examination of patients with [[appendix cancer]] is usually normal.
* [[Wheezing]] : if the patient develop carcinoid syndrome  
* [[Wheezing]] : If the patient develop [[carcinoid syndrome]].
===Heart===
===Heart===
* Cardiovascular examination of patients with appendix cancer is usually normal.
* [[Circulatory system|Cardiovascular]] examination of patients with appendix cancer is usually normal.
* If the patient develop carcinoid syndrome [[Murmur|systolic or diastolic murmur]] might be present
* If the patient develop [[carcinoid syndrome]] [[Murmur|systolic or diastolic murmur]] might be present.
* Right heart murmurs specially TR is prevalent.
* Right [[Heart murmur|heart murmurs]] specially [[Tricuspid regurgitation|TR]] is prevalent.


===Abdomen===
===Abdomen===
* Considering small size of must of appendiceal tumors, abdominal examination of patients with appendix cancer is usually normal.
* Considering small size of must of appendiceal [[Tumor|tumors]], abdominal examination of patients with appendix cancer is usually normal.
* but in the cases of cimplicated tumors likeappendicits ot perforated appendicitis, abdominal examination may be remarkable for:
* But in the cases of complicated tumors such as perforated [[appendicitis]], [[abdominal examination]] may be remarkable for:
*[[Abdominal tenderness]] in the right lower abdominal quadrant  
**[[Abdominal tenderness]] in the right lower abdominal quadrant  
*[[Rebound tenderness]]  
**[[Rebound tenderness]]  
*A palpable abdominal mass in the right lower abdominal quadrant
**A palpable [[abdominal mass]] in the right lower abdominal quadrant
*Guarding may be present
**[[Abdominal guarding|Guarding]] may be present
*In cases of late stage metastatic disease [[hepatosplenomegaly]] might be present
*In cases of late stage [[metastatic]] disease [[hepatosplenomegaly]] might be present.
*Additional findings, such as obturator test, psoas test, McBurney point test are common in appendicitis
*Additional findings, such as [[obturator]] test, [[Psoas sign|Psoas]] test, McBurney point test are common in [[Appendicitis diagnostic scoring|appendicitis]].
'''''Palpation'''''
'''''Palpation'''''
* The abdominal wall is very sensitive to mild palpation
* The abdominal wall is very sensitive to mild palpation:
* [[Rebound tenderness]]
** [[Rebound tenderness]]
* [[Abdominal guarding]]
** [[Abdominal guarding]]
* [[Rovsing's sign]]
** [[Rovsing's sign]]
* [[Psoas sign]]
** [[Psoas sign]]
'''''Rectal examination'''''
'''''Rectal examination'''''
* Tenderness in the [[rectovesical pouch]]
* [[Tenderness]] in the [[rectovesical pouch]]


===Back===
===Back===
* Back examination of patients with appendix cancer is usually normal
* Back examination of patients with appendix cancer is usually normal.
===Genitourinary===
===Genitourinary===
* Genitourinary examination of patients with [disease name] is usually normal.
* [[Genitourinary tract|Genitourinary]] examination of patients with appendix cancer is usually normal.
OR
 
*A pelvic/adnexal mass may be palpated
*A pelvic [[Adnexal mass causes|adnexal mass]] may be palpated; in fact a number of appendiceal cancers are misdiagnosed as [[Ovarian cancer|ovarian masses]] vise versa.
*Inflamed mucosa
*Clear/(color), foul-smelling/odorless penile/vaginal discharge


===Neuromuscular===
===Neuromuscular===
* Neuromuscular examination of patients with [disease name] is usually normal.
* Neuromuscular examination of patients with appendix cancer is usually normal.  
OR
* [[Dementia]], aggression, and [[mental confusion]] are rare complications of complicated [[carcinoid syndrome]] patients that develop [[Pellagra]].
*Patient is usually oriented to persons, place, and time
* Altered mental status
* Glasgow coma scale is ___ / 15
* Clonus may be present
* Hyperreflexia / hyporeflexia / areflexia
* Positive (abnormal) Babinski / plantar reflex unilaterally/bilaterally
* Muscle rigidity
* Proximal/distal muscle weakness unilaterally/bilaterally
* ____ (finding) suggestive of cranial nerve ___ (roman numerical) deficit (e.g. Dilated pupils suggestive of CN III deficit)
*Unilateral/bilateral upper/lower extremity weakness
*Unilateral/bilateral sensory loss in the upper/lower extremity
*Positive straight leg raise test
*Abnormal gait (describe gait: e.g. ataxic (cerebellar) gait / steppage gait / waddling gait / choeiform gait / Parkinsonian gait / sensory gait)
*Positive/negative Trendelenburg sign
*Unilateral/bilateral tremor (describe tremor, e.g. at rest, pill-rolling)
*Normal finger-to-nose test / Dysmetria
*Absent/present dysdiadochokinesia (palm tapping test)
 
===Extremities===
===Extremities===
* Extremities examination of patients with appendix cancer is usually normal.
* [[Limb (anatomy)|Extremities]] examination of patients with appendix cancer is usually normal.


*rarely patients with carcionid syndrome might present with [[Edema|lower limb edema]]
*Rarely patients with [[Carcinoid syndrome|carcinoid]] syndrome might present with [[Edema|lower limb edema]].


==References==
==References==
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[[Category:Up-To-Date]]

Latest revision as of 17:49, 22 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]

Overview

Patients with appendix cancer usually appear normal, pale or diaphoretic. If the patient with appendix cancer present with acute appendicitis which is quite common, abdominal tenderness, rebound tenderness, abdominal guarding, Rovsing's sign, as well as Psoas sign might be present. Around 5% of the patients with appendiceal carcinoid tumors might develop carcinoid syndrome. Common physical examination findings of carcinoid syndrome include dehydration due to diarrhea, tachycardia as well as facial flushing, right heart murmurs like TR murmur is quit common. In patients with carcinoid syndrome, the presence of dermatitis, diarrhea, and dementia on physical examination is highly suggestive of Pellagra disease.

Physical Examination

Appearance of the Patient

  • Patients with appendix cancer usually appear normal but might be pale or diaphoretic, or even present with a facial flushing.

Vital Signs

Skin

HEENT

  • HEENT examination of patients with appendix cancer is usually normal.
  • Glossitis may be suggestive of Pellagra.

Neck

Lungs

Heart

Abdomen

Palpation

Rectal examination

Back

  • Back examination of patients with appendix cancer is usually normal.

Genitourinary

  • Genitourinary examination of patients with appendix cancer is usually normal.

Neuromuscular

Extremities

  • Extremities examination of patients with appendix cancer is usually normal.

References

  1. Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019
  2. Hardin, M. Acute Appendicitis: Review and Update. Am Fam Physician".1999, Nov 1;60(7):2027-2034
  3. Signs and symptoms of carcinoid syndrome. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/patient/gi-carcinoid-treatment-pdq
  4. Hegyi J, Schwartz RA, Hegyi V (2004) Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol 43 (1):1-5. PMID: 14693013

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