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(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...)
(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...)
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===Diagnosis and Evaluation of aplastic anemia===
===Diagnosis and Evaluation of [[aplastic anemia]]===
* Careful history and clinical examination
* Careful history and clinical examination
* Detailed drug and occupational exposure history
* Detailed drug and occupational exposure history
* Patients presenting with aplastic anaemia should be assessed to:
* Patients presenting with aplastic anaemia should be assessed to:
** Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow
** Confirm the diagnosis and exclude other possible causes of [[pancytopenia]] with hypocellular [[bone marrow]]
** Classify the disease severity using standard blood and bone marrow criteria
** Classify the disease severity using standard blood and bone marrow criteria
** Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones
** Document the presence of associated [[paroxysmal nocturnal haemoglobinuria]] (PNH) and cytogenetic clones
** Exclude a possible late onset inherited bone marrow failure disorder
** Exclude a possible late onset inherited bone marrow failure disorder
* Multidisciplinary approach
* Multidisciplinary approach

Revision as of 14:27, 23 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Aplastic anemia is seen as a result of hypoplastic bone marrow causing pancytopenia (anemia, neutropenia, thrombocytopenia). The history and symptoms seen are secondary to these abnormalities.

Symptoms

Diagnosis and management of aplastic anemia [1] (DONOT EDIT)

Diagnosis and Evaluation of aplastic anemia

  • Careful history and clinical examination
  • Detailed drug and occupational exposure history
  • Patients presenting with aplastic anaemia should be assessed to:
    • Confirm the diagnosis and exclude other possible causes of pancytopenia with hypocellular bone marrow
    • Classify the disease severity using standard blood and bone marrow criteria
    • Document the presence of associated paroxysmal nocturnal haemoglobinuria (PNH) and cytogenetic clones
    • Exclude a possible late onset inherited bone marrow failure disorder
  • Multidisciplinary approach
  • Referral to specialist if necessary

References

  1. Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.