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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Varun Kumar, M.B.B.S.; Lakshmi Gopalakrishnan, M.B.B.S.

Prevalence

There are two broad underlying causes of aortic regurgitation:

  1. Disease of the aortic valve itself and
  2. Disease of the aortic root leading to dilation and regurgitation of the aortic valve

Aortic regurgitation secondary to dilation of the ascending aorta has overtaken valvular aortic disease as the most common cause of aortic regurgitation.

The prevalence of aortic insufficiency increases with age[1] [2]with higher severity in men than in women. [3] [4]

Developing Countries

In developing countries, rheumatic heart disease is the most common cause of aortic insufficiency and may present in second or third decade of life.

Developed Countries

In developedcountries where rheumatic heart disease is rare, aortic insufficiency may be due to bi-cuspid aortic valve disease or degenerative disease which may present in the fourth to sixth decade. Endocarditis and aortic dissection are other causes.

References

  1. Singh JP, Evans JC, Levy D, Larson MG, Freed LA, Fuller DL, Lehman B, Benjamin EJ (1999). "Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)". The American Journal of Cardiology. 83 (6): 897–902. PMID 10190406. Retrieved 2011-03-02. Unknown parameter |month= ignored (help)
  2. Lebowitz NE, Bella JN, Roman MJ, Liu JE, Fishman DP, Paranicas M, Lee ET, Fabsitz RR, Welty TK, Howard BV, Devereux RB (2000). "Prevalence and correlates of aortic regurgitation in American Indians: the Strong Heart Study". Journal of the American College of Cardiology. 36 (2): 461–7. PMID 10933358. Retrieved 2011-03-02. Unknown parameter |month= ignored (help)
  3. Klodas E, Enriquez-Sarano M, Tajik AJ, Mullany CJ, Bailey KR, Seward JB (1997). "Optimizing timing of surgical correction in patients with severe aortic regurgitation: role of symptoms". Journal of the American College of Cardiology. 30 (3): 746–52. PMID 9283535. Retrieved 2011-03-02. Unknown parameter |month= ignored (help)
  4. Dujardin KS, Enriquez-Sarano M, Schaff HV, Bailey KR, Seward JB, Tajik AJ (1999). "Mortality and morbidity of aortic regurgitation in clinical practice. A long-term follow-up study". Circulation. 99 (14): 1851–7. PMID 10199882. Retrieved 2011-03-02. Unknown parameter |month= ignored (help)

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