Aortic dissection natural history, complications and prognosis: Difference between revisions
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The complications of aortic dissection include: | The complications of aortic dissection include: | ||
=== Cardiac=== | === Cardiac=== | ||
====[[Aortic rupture]] | ====Aortic Rupture==== | ||
[[Aortic rupture]] leads to [[massive blood loss]], [[hypotension]] and [[shock]] often resulting in death. Indeed, aortic dissection accounts for 3-4% of [[sudden deaths]]. | |||
====Pericardial Tamponade==== | |||
[[Pericardial tamponade]] can occur due to extension of the dissection into the pericardium. | |||
====Acute Aortic Regurgitation==== | |||
[[Acute aortic regurgitation]]due to the aortic dilation and dissection into the valve structure which can then cause acute [[pulmonary edema]]. [[Aortic insufficiency]] (AI) occurs in 1/2 to 2/3 of ascending aortic dissections, and the [[heart sounds|murmur]] of aortic insufficiency is audible in about 32% of proximal dissections. The intensity (loudness) of the murmur is dependent on the blood pressure and may be inaudible in the event of [[hypotension]]. There are multiple etiologies for AI in the setting of ascending aortic dissection. The dissection may dilate the annulus of the [[aortic valve]], so that the leaflets of the valve cannot coapt. Another mechanism is that the dissection may extend into the aortic root and detach the aortic valve leaflets. The third mechanism is that if there was an extensive intimal tear, the intimal flap may prolapse into the LV outflow tract, causing intimal [[intussusception]] into the aortic valve preventing proper valve closure. | |||
====Myocardial Infarction==== | |||
[[Myocardial ischemia]] or [[myocardial infarction]] due to dissection into either the right or left coronary ostium (but most commonly the [[right coronary artery]]). [[Myocardial infarction]] (heart attack) occurs in 1-2% of aortic dissections. The etiology of the infarction is involvement of the [[coronary artery|coronary arteries]] (the [[artery|arteries]] that supply the heart) in the dissection. The right coronary artery is involved more commonly than the left coronary artery. If the myocardial infarction is treated with [[thrombolytic]] therapy, the mortality increases to over 70%, mostly due to hemorrhage into the pericardial sac causing [[pericardial tamponade]]. Because aortic dissection may present to the [[emergency room]] [[physician]] similar to a myocardial infarction, the physician must be careful to make the proper diagnosis prior to initiating treatment for myocardial infarction, since the treatment regimen for myocardial infarction can be lethal to an individual presenting with aortic dissection. | |||
====Thoracic Aortic Aneurysm==== | |||
Redissection and aortic diameter enlargement as well as aneurysmal dilatation and [[saccular aneurysm]] chronically. | |||
===Kidney=== | ===Kidney=== | ||
[[Renal ischemia]] due to dissection into the ostium of the renal vessels can lead to [[hematuria]], [[renal infarction]], [[acute renal failure]] | |||
===Messentery=== | |||
Visceral ischemia can occur due to extension of the dissection into the [[superior mesenteric artery]]. | |||
===Peripheral Arterial=== | ===Peripheral Arterial=== | ||
[[Claudication]] can occur due to an extension of the dissection into the iliac arteries. | |||
===Neurologic=== | ===Neurologic=== | ||
Revision as of 00:19, 29 October 2012
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Aortic dissection Microchapters |
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Diagnosis |
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Treatment |
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Special Scenarios |
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Case Studies |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Aortic dissection carries a very poor prognosis. 90% of patients who are untreated will be dead at one year. Type A dissection is associated with a worse prognosis than type B dissection. Aortic dissection can be complicated by extension to the coronary arteries resulting in myocardial infarction, involvement of the aortic arch to cause stroke, dilation of the route to cause aortic insufficiency, extension into the pericardium to cause pericardial tamponade, and heart failure, and aortic rupture.
Natural History
If the patient remains untreated, the mortality is:
- 1% per hour during the first day
- 75% at 2 weeks
- 90% at 1 year
Complications
The complications of aortic dissection include:
Cardiac
Aortic Rupture
Aortic rupture leads to massive blood loss, hypotension and shock often resulting in death. Indeed, aortic dissection accounts for 3-4% of sudden deaths.
Pericardial Tamponade
Pericardial tamponade can occur due to extension of the dissection into the pericardium.
Acute Aortic Regurgitation
Acute aortic regurgitationdue to the aortic dilation and dissection into the valve structure which can then cause acute pulmonary edema. Aortic insufficiency (AI) occurs in 1/2 to 2/3 of ascending aortic dissections, and the murmur of aortic insufficiency is audible in about 32% of proximal dissections. The intensity (loudness) of the murmur is dependent on the blood pressure and may be inaudible in the event of hypotension. There are multiple etiologies for AI in the setting of ascending aortic dissection. The dissection may dilate the annulus of the aortic valve, so that the leaflets of the valve cannot coapt. Another mechanism is that the dissection may extend into the aortic root and detach the aortic valve leaflets. The third mechanism is that if there was an extensive intimal tear, the intimal flap may prolapse into the LV outflow tract, causing intimal intussusception into the aortic valve preventing proper valve closure.
Myocardial Infarction
Myocardial ischemia or myocardial infarction due to dissection into either the right or left coronary ostium (but most commonly the right coronary artery). Myocardial infarction (heart attack) occurs in 1-2% of aortic dissections. The etiology of the infarction is involvement of the coronary arteries (the arteries that supply the heart) in the dissection. The right coronary artery is involved more commonly than the left coronary artery. If the myocardial infarction is treated with thrombolytic therapy, the mortality increases to over 70%, mostly due to hemorrhage into the pericardial sac causing pericardial tamponade. Because aortic dissection may present to the emergency room physician similar to a myocardial infarction, the physician must be careful to make the proper diagnosis prior to initiating treatment for myocardial infarction, since the treatment regimen for myocardial infarction can be lethal to an individual presenting with aortic dissection.
Thoracic Aortic Aneurysm
Redissection and aortic diameter enlargement as well as aneurysmal dilatation and saccular aneurysm chronically.
Kidney
Renal ischemia due to dissection into the ostium of the renal vessels can lead to hematuria, renal infarction, acute renal failure
Messentery
Visceral ischemia can occur due to extension of the dissection into the superior mesenteric artery.
Peripheral Arterial
Claudication can occur due to an extension of the dissection into the iliac arteries.
Neurologic
- Ischemic cerebrovascular accident (CVA) due to dissection into the head vessels
- Hemiplegia due to dissection into the spinal arteries
- Hemianesthesia due to dissection into the spinal arteries
Compression of Nearby Organs
- Swelling of the neck and face (compression of the superior vena cava or Superior vena cava syndrome)
- Horner syndrome (compression of the superior cervical ganglia)
- Dysphagia (compression of the esophagus)
- Stridor and wheezing (compression of the airway)
- Hemoptysis (compression of and erosion into the bronchus)
- Vocal cord paralysis and hoarseness (compression of the recurrent laryngeal nerve)
Prognosis
The mortality rate is in large part determined by the patient's age and comorbidities.
- 30% in hospital mortality
- 60% 10-year survival rate among treated patients
Type A aortic dissection
- Surgical treatment-30% mortality rate
- Medical treatment-60% mortality rate
Type B aortic dissection
- Surgical treatment-10% mortality rate
- Medical treatment- 30% mortality rate