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'''Anti-citrullinated protein antibodies''' (ACPA) or '''anti-cyclic citrullinated protein antibodies''' (anti-CCP) are [[autoantibody|autoantibodies]] (antibodies against human tissues) frequently detected in [[rheumatoid arthritis]]. The main [[epitope]] for these antibodies is [[filaggrin]], and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.<ref>{{cite journal |author=Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ |title=Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies |journal=J. Clin. Invest. |volume=101 |issue=1 |pages=273–81 |year=1998 |month=January |pmid=9421490 |doi=10.1172/JCI1316 |url=http://www.jci.org/articles/view/1316}} {{PMC|508564}}</ref> In a comparative study, various detection kits had a [[sensitivity (test)|sensitivity]] between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.<ref>{{cite journal |author=Coenen D, Verschueren P, Westhovens R, Bossuyt X |title=Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis |journal=Clin. Chem. |volume=53 |issue=3 |pages=498–504 |year=2007 |month=March |pmid=17259232 |doi=10.1373/clinchem.2006.078063 |url=http://www.clinchem.org/cgi/content/full/53/3/498}}</ref> Given that ACPA is more specific than [[rheumatoid factor]], it is used to distinguish various causes of arthritis.<ref>{{cite journal |author=Avouac J, Gossec L, Dougados M |title=Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review |journal=Ann. Rheum. Dis. |volume=65 |issue=7 |pages=845–51 |year=2006 |month=July |pmid=16606649 |doi=10.1136/ard.2006.051391 |url=http://ard.bmj.com/cgi/content/full/65/7/845}}</ref>
'''Anti-citrullinated protein antibodies''' (ACPA) or '''anti-cyclic citrullinated protein antibodies''' (anti-CCP) are [[autoantibody|autoantibodies]] (antibodies against human tissues) frequently detected in [[rheumatoid arthritis]]. The main [[epitope]] for these antibodies is [[filaggrin]], and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.<ref>{{cite journal |author=Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ |title=Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies |journal=J. Clin. Invest. |volume=101 |issue=1 |pages=273–81 |year=1998 |month=January |pmid=9421490 |doi=10.1172/JCI1316 |url=http://www.jci.org/articles/view/1316}} {{PMC|508564}}</ref> In a comparative study, various detection kits had a [[sensitivity (test)|sensitivity]] between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.<ref>{{cite journal |author=Coenen D, Verschueren P, Westhovens R, Bossuyt X |title=Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis |journal=Clin. Chem. |volume=53 |issue=3 |pages=498–504 |year=2007 |month=March |pmid=17259232 |doi=10.1373/clinchem.2006.078063 |url=http://www.clinchem.org/cgi/content/full/53/3/498}}</ref> Given that ACPA is more specific than [[rheumatoid factor]], it is used to distinguish various causes of arthritis.<ref>{{cite journal |author=Avouac J, Gossec L, Dougados M |title=Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review |journal=Ann. Rheum. Dis. |volume=65 |issue=7 |pages=845–51 |year=2006 |month=July |pmid=16606649 |doi=10.1136/ard.2006.051391 |url=http://ard.bmj.com/cgi/content/full/65/7/845}}</ref>
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{{Autoantibodies}}
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[[Category:Blood test]]
[[Category:Blood tests]]
[[Category:Rheumatology]]
[[Category:Rheumatology]]
[[Category:Autoantibodies|C]]
[[Category:Autoantibodies|C]]

Latest revision as of 22:18, 8 August 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Anti-citrullinated protein antibodies (ACPA) or anti-cyclic citrullinated protein antibodies (anti-CCP) are autoantibodies (antibodies against human tissues) frequently detected in rheumatoid arthritis. The main epitope for these antibodies is filaggrin, and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.[1] In a comparative study, various detection kits had a sensitivity between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.[2] Given that ACPA is more specific than rheumatoid factor, it is used to distinguish various causes of arthritis.[3]

References

  1. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998). "Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies". J. Clin. Invest. 101 (1): 273–81. doi:10.1172/JCI1316. PMID 9421490. Unknown parameter |month= ignored (help) PMC 508564
  2. Coenen D, Verschueren P, Westhovens R, Bossuyt X (2007). "Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis". Clin. Chem. 53 (3): 498–504. doi:10.1373/clinchem.2006.078063. PMID 17259232. Unknown parameter |month= ignored (help)
  3. Avouac J, Gossec L, Dougados M (2006). "Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review". Ann. Rheum. Dis. 65 (7): 845–51. doi:10.1136/ard.2006.051391. PMID 16606649. Unknown parameter |month= ignored (help)


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