Amiodarone overdose

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

There have been cases, some fatal, of Amiodarone overdose.

In addition to general supportive measures, the patient's cardiac rhythm and blood pressure should be monitored, and if bradycardia ensues, a β-adrenergic agonist or a pacemaker may be used. Hypotension with inadequate tissue perfusion should be treated with positive inotropic and/or vasopressor agents. Neither Amiodarone nor its metabolite is dialyzable.

The acute oral LD₅₀ of Amiodarone HCl in mice and rats is greater than 3,000 mg/kg.

Adapted from the FDA Package Insert.