Aminosalicylic acid: Difference between revisions

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{{DrugProjectFormSinglePage
{{Aminosalicylic acid}}
|authorTag=<!--Overview-->
{{CMG}}; {{AE}} {{chetan}}
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{{SK}} ''para''-aminosalicylic acid, ''p''-aminosalicylic acid or 4-aminosalicylic acid; abbreviated 4-ASA, or PAS
* Content


==Overview==
<!--Adult Indications and Dosage-->
Aminosalicylic acid is an [[antibiotic]] used to treat [[tuberculosis]]. It has been use for over forty years in the treatment of [[inflammatory bowel disease|inflammatory bowel disease (IBD)]], where it has shown greater potency in [[Crohn's disease]]. It is thought to act via [[NF-kB|NF-κB (nuclear factor-kappa B)]] inhibition and [[free radical]] scavenging.


Aminosalicylic acid is sold in the [[United States]] by [[Jacobus Pharmaceutical]] as PASER<sup>®</sup>.
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====


[[Mesalazine]] (5-aminosalicylic acid) is a closely related compound that also has medical uses.
* Dosing Information


==Category==
:* Dosage
Antimycobacterial


==US Brand Names==
=====Condition2=====
PASER<sup>®</sup>


==FDA Package Insert==
* Dosing Information
'''[[Aminosalicylic acid description|Description]]'''
'''| [[Aminosalicylic acid clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Aminosalicylic acid microbiology|Microbiology]]'''
'''| [[Aminosalicylic acid indications and usage|Indications and Usage]]'''
'''| [[Aminosalicylic acid contraindications|Contraindications]]'''
'''| [[Aminosalicylic acid warnings and precautions|Warnings and Precautions]]'''
'''| [[Aminosalicylic acid adverse reactions|Adverse Reactions]]'''
'''| [[Aminosalicylic acid overdosage|Overdosage]]'''
'''| [[Aminosalicylic acid dosage and administration|Dosage and Administration]]'''
'''| [[Aminosalicylic acid how supplied|How Supplied]]'''
'''| [[Aminosalicylic acid labels and packages|Labels and Packages]]'''


==Mechanism of Action==
:* Dosage
Aminosalicylic acid is an analogue of [[para-aminobenzoic acid|para-aminobenzoic acid (PABA)]] and acts as a competitive inhibitor of [[dihydropteroate synthetase|dihydropteroate synthase 1 (folP1)]]. Its competitive antagonism with PABA is similar to the action of [[sulfonamides]] which disrupts biosynthesis in sensitive organisms. Aminosalicylic acid is [[bacteriostatic]] against ''[[Mycobacterium tuberculosis]]''. It inhibits the onset of bacterial resistance to [[streptomycin]] and [[isoniazid]]. Other mechanism of action has been postulated to be inhibition of synthesis of the cell wall component, mycobactin, thus reducing iron uptake by ''[[M. tuberculosis]]''.


==References==
=====Condition3=====
{{Reflist|2}}


[[Category:Antibiotics]]
* Dosing Information
[[Category:Wikinfect]]
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
<!--Guideline-Supported Use (Adult)-->
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* Class of Recommendation:
 
* Strength of Evidence:
 
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* Dosing Information
 
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<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
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* Dosing Information
 
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=====Respiratory=====
 
 
 
 
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=====Special Senses=====
 
 
 
 
=====Urogenital=====
 
 
 
 
=====Miscellaneous=====
 
 
 
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====Management====
 
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[[Category:Drug]]

Revision as of 19:43, 17 February 2015

Aminosalicylic acid
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Aminosalicylic acid is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Aminosalicylic acid in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Aminosalicylic acid in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Aminosalicylic acid in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Aminosalicylic acid in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Aminosalicylic acid in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Aminosalicylic acid in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Aminosalicylic acid in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Aminosalicylic acid in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Aminosalicylic acid during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Aminosalicylic acid with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Aminosalicylic acid with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Aminosalicylic acid with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Aminosalicylic acid with respect to specific gender populations.

Race

There is no FDA guidance on the use of Aminosalicylic acid with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Aminosalicylic acid in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Aminosalicylic acid in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Aminosalicylic acid in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Aminosalicylic acid in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Aminosalicylic acid in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Aminosalicylic acid in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Aminosalicylic acid in the drug label.

Pharmacology

There is limited information regarding Aminosalicylic acid Pharmacology in the drug label.

Mechanism of Action

Structure

File:Aminosalicylic acid01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Aminosalicylic acid in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Aminosalicylic acid in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Aminosalicylic acid in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Aminosalicylic acid in the drug label.

How Supplied

Storage

There is limited information regarding Aminosalicylic acid Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Aminosalicylic acid |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Aminosalicylic acid |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Aminosalicylic acid in the drug label.

Precautions with Alcohol

  • Alcohol-Aminosalicylic acid interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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