Aminopropionitrile: Difference between revisions
Jump to navigation
Jump to search
(Created page with "{{Chembox | ImageFileL1 = aminopropionitrile.png | ImageFileL1_Ref = {{chemboximage|correct|??}} | ImageSizeL1 = 110 | ImageAltL1 = Structural formula of aminopropionitrile |...") |
No edit summary |
||
Line 4: | Line 4: | ||
| ImageSizeL1 = 110 | | ImageSizeL1 = 110 | ||
| ImageAltL1 = Structural formula of aminopropionitrile | | ImageAltL1 = Structural formula of aminopropionitrile | ||
| ImageFileR1 = | | ImageFileR1 = Aminopropionitrile_3D_ball.png | ||
| ImageSizeR1 = 130 | | ImageSizeR1 = 130 | ||
| ImageAltR1 = Ball-and-stick model of the aminopropionitrile molecule | | ImageAltR1 = Ball-and-stick model of the aminopropionitrile molecule | ||
Line 52: | Line 52: | ||
}} | }} | ||
}} | }} | ||
__NOTOC__ | |||
{{SI}} | |||
{{CMG}} | |||
==Overview== | |||
'''Aminopropionitrile''', also known as '''β-aminopropionitrile''' ('''BAPN'''), is an [[organic compound]] with both [[amine]] and [[nitrile]] [[functional group]]s. It is an [[antirheumatic]] agent in veterinary medicine. It can cause [[osteolathyrism]], [[neurolathyrism]], and/or [[angiolathyrism]].<ref>{{cite journal|title=Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection|journal=Blood|volume=120|issue=9|pages=1774–1781|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433087/|quote=BAPN is a lathyrogen, the toxic constituent of peas from Lathyrus plants. Lathyrism, a disease known for centuries, encompasses 2 distinct entities: a disorder of the nervous system (neurolathyrism) leading to limb paralysis, and a disorder of connective tissue, causing either bone deformity (osteolathyrism) or aortic aneurisms (angiolathyrim). BAPN causes osteolathyrism and angiolathyrism when ingested in large quantities.|author=Nikolaos Papadantonakis, Shinobu Matsuura, and Katya Ravid|doi=10.1182/blood-2012-02-402594}}</ref> | '''Aminopropionitrile''', also known as '''β-aminopropionitrile''' ('''BAPN'''), is an [[organic compound]] with both [[amine]] and [[nitrile]] [[functional group]]s. It is an [[antirheumatic]] agent in veterinary medicine. It can cause [[osteolathyrism]], [[neurolathyrism]], and/or [[angiolathyrism]].<ref>{{cite journal|title=Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection|journal=Blood|volume=120|issue=9|pages=1774–1781|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433087/|quote=BAPN is a lathyrogen, the toxic constituent of peas from Lathyrus plants. Lathyrism, a disease known for centuries, encompasses 2 distinct entities: a disorder of the nervous system (neurolathyrism) leading to limb paralysis, and a disorder of connective tissue, causing either bone deformity (osteolathyrism) or aortic aneurisms (angiolathyrim). BAPN causes osteolathyrism and angiolathyrism when ingested in large quantities.|author=Nikolaos Papadantonakis, Shinobu Matsuura, and Katya Ravid|doi=10.1182/blood-2012-02-402594}}</ref> | ||
Aminopropionitrile is prepared by the reaction of [[ammonia]] with [[acrylonitrile]].<ref name=Ullmann>Karsten Eller, Erhard Henkes, Roland Rossbacher, Hartmut Höke "Amines, Aliphatic" in ''Ullmann's Encyclopedia of Industrial Chemistry'', Wiley-VCH, Weinheim, 2005. {{DOI|10.1002/14356007.a02_001}}</ref> | Aminopropionitrile is prepared by the reaction of [[ammonia]] with [[acrylonitrile]].<ref name=Ullmann>Karsten Eller, Erhard Henkes, Roland Rossbacher, Hartmut Höke "Amines, Aliphatic" in ''Ullmann's Encyclopedia of Industrial Chemistry'', Wiley-VCH, Weinheim, 2005. {{DOI|10.1002/14356007.a02_001}}</ref> | ||
BAPN is a component of '' | BAPN is a component of ''lathyrus odoratus''.<ref>{{cite web|url=http://www.aacc.org/members/divisions/tdm/library/Pages/april08.aspx|title=Lathyrus|year=2014|publisher=[[American Association for Clinical Chemistry]]|accessdate=15 October 2014|location=[[Washington, DC]]|quote=Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (our more common garden sweet pea plant) is thought to be responsible for osteolathyrism, which in humans is quite poorly documented.}}</ref> | ||
==See also== | ==See also== | ||
* [[Lysyl oxidase]] | * [[Lysyl oxidase]] | ||
* [[Marfan syndrome]] | * [[Marfan syndrome]] | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist|2}} | ||
[[Category:Amines]] | [[Category:Amines]] | ||
[[Category:Drug]] | |||
[[Category:Nitriles]] | [[Category:Nitriles]] |
Revision as of 20:05, 10 April 2015
Template:Chembox 3DMetTemplate:Chembox BeilsteinTemplate:Chembox ECNumberTemplate:Chembox E numberTemplate:Chembox GmelinTemplate:Chembox RTECSTemplate:Chembox AppearanceTemplate:Chembox BoilingPt
Template:Chembox image sbs cell | |
Names | |
---|---|
IUPAC name
3-Aminopropanenitrile[1]
| |
Other names
2-Cyanoethylamine[citation needed]
| |
Identifiers | |
3D model (JSmol)
|
|
ChEBI | |
ChemSpider | |
ECHA InfoCard | Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). |
KEGG | |
MeSH | Aminopropionitrile |
PubChem CID
|
|
UNII | |
| |
| |
Properties | |
C3H6N2 | |
Molar mass | 70.10 g·mol−1 |
Related compounds | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. It is an antirheumatic agent in veterinary medicine. It can cause osteolathyrism, neurolathyrism, and/or angiolathyrism.[2]
Aminopropionitrile is prepared by the reaction of ammonia with acrylonitrile.[3]
BAPN is a component of lathyrus odoratus.[4]
See also
References
- ↑ "Aminopropionitrile - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Retrieved 7 June 2012.
- ↑ Nikolaos Papadantonakis, Shinobu Matsuura, and Katya Ravid. "Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection". Blood. 120 (9): 1774–1781. doi:10.1182/blood-2012-02-402594.
BAPN is a lathyrogen, the toxic constituent of peas from Lathyrus plants. Lathyrism, a disease known for centuries, encompasses 2 distinct entities: a disorder of the nervous system (neurolathyrism) leading to limb paralysis, and a disorder of connective tissue, causing either bone deformity (osteolathyrism) or aortic aneurisms (angiolathyrim). BAPN causes osteolathyrism and angiolathyrism when ingested in large quantities.
- ↑ Karsten Eller, Erhard Henkes, Roland Rossbacher, Hartmut Höke "Amines, Aliphatic" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. doi:10.1002/14356007.a02_001
- ↑ "Lathyrus". Washington, DC: American Association for Clinical Chemistry. 2014. Retrieved 15 October 2014.
Beta-amino-propionitrile (BAPN) found in lathyrus odoratus (our more common garden sweet pea plant) is thought to be responsible for osteolathyrism, which in humans is quite poorly documented.
Categories:
- Pages with script errors
- CS1 maint: Multiple names: authors list
- All articles with unsourced statements
- Articles with unsourced statements from June 2012
- Articles with invalid date parameter in template
- Articles without InChI source
- Chemical articles with unknown parameter in Chembox
- ECHA InfoCard ID from Wikidata
- Articles containing unverified chemical infoboxes
- Chembox image size set
- Amines
- Drug
- Nitriles