- an N-acyl-L-amino acid + H2O a carboxylate + an L-amino acid
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acyl-L-amino-acid amidohydrolase. Other names in common use include dehydropeptidase II, histozyme, hippuricase, benzamidase, acylase I, hippurase, amido acid deacylase, L-aminoacylase, acylase, aminoacylase I, L-amino-acid acylase, alpha-N-acylaminoacid hydrolase, long acyl amidoacylase, and short acyl amidoacylase. This enzyme participates in urea cycle and metabolism of amino groups.
- IUBMB entry for 184.108.40.206
- BRENDA references for 220.127.116.11 (Recommended.)
- PubMed references for 18.104.22.168
- PubMed Central references for 22.214.171.124
- Google Scholar references for 126.96.36.199
- BIRNBAUM SM, LEVINTOW L, KINGSLEY RB, GREENSTEIN JP (1952). "Specificity of amino acid acylases". J. Biol. Chem. 194: 455&ndash, 70. PMID 14927637.
- FONES WS, LEE M (1953). "Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase". J. Biol. Chem. 201: 847&ndash, 56. PMID 13061423.
- Park RW and Fox, SW (1960). "An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus". J. Biol. Chem. 235: 3193&ndash, 3197.
- The CAS registry number for this enzyme class is 9012-37-7.
Gene Ontology (GO) codes
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