Alvimopan

Alvimopan
	File:Alvimopan.svg
Clinical data
Synonyms	Alvimopan, Entereg
Identifiers
	IUPAC name 2-([(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl) -3-phenylpropanoyl]amino)acetic acid;
CAS Number	156053-89-3;
PubChem CID	5488548;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C25H32N2O4
Molar mass	424.53 g/mol

Alvimopan (Entereg) is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood-brain barrier, many of the undesirable side-effects of the opioid agonists such as constipation are minimized without affecting analgesia or precipitating withdrawals.

References

Neary P, Delaney P (2005). "Alvimopan". Expert Opin Investig Drugs. 14 (4): 479–88. PMID 15882122.

Schmidt WK (2001). "Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist". Am J Surg. 182 (5A Supp): 27S–38S. PMID 11755894.