Altitude sickness laboratory findings: Difference between revisions

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==Overview==
==Overview==
Chronic mountain sickness (CMS) is characterized by [[polycythemia]] (increased [[hematocrit]]) and [[hypoxemia]] which both decrease on descent from altitude.  CMS is believed to arise because of an excessive production of [[red blood cell]]s, which increases the oxygen carrying capacity of the blood but may cause increased blood viscosity and uneven blood flow through the lungs ([[V/Q mismatch]]). However, CMS is also considered an adaptation of pulmonary and [[heart disease]] to life under chronic [[hypoxia]] at altitude.<ref name="pmid17072074">{{cite journal| author=Zubieta-Castillo G, Zubieta-Calleja GR, Zubieta-Calleja L| title=Chronic mountain sickness: the reaction of physical disorders to chronic hypoxia. | journal=J Physiol Pharmacol | year= 2006 | volume= 57 Suppl 4 | issue= | pages= 431-42 | pmid=17072074 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17072074  }} </ref> [[Clinical]] diagnosis by laboratory indicators have ranges of: [[Hemoglobin|Hb]] > 200 g/L, [[Hematocrit|Hct]] > 65%, and [[arterial oxygen saturation]] (SaO2) < 85% in both genders.<ref name="pmid20586602">{{cite journal| author=West JB| title=English translation of "Nomenclature, classification, and diagnostic criteria of high altitude disease in China". | journal=High Alt Med Biol | year= 2010 | volume= 11 | issue= 2 | pages= 169-72 | pmid=20586602 | doi=10.1089/ham.2010.1014 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20586602  }} </ref>
Laboratory findings consistent with the diagnosis of altitude sickness include increased the level of [[hemoglobin]], [[hematocrit]] and [[blood urea nitrogen]] and decreased level of [[bicarbonate]], [[creatinine]] and [[PCO2]].
 
==Laboratory Findings==
*Laboratory findings consistent with the diagnosis of altitude sickness include:<ref name="pmid17078312">{{cite journal |vauthors=Shah MB, Braude D, Crandall CS, Kwack H, Rabinowitz L, Cumbo TA, Basnyat B, Bhasyal G |title=Changes in metabolic and hematologic laboratory values with ascent to altitude and the development of acute mountain sickness in Nepalese pilgrims |journal=Wilderness Environ Med |volume=17 |issue=3 |pages=171–7 |date=2006 |pmid=17078312 |doi= |url=}}</ref>
**Increased [[Hemoglobin]] (Hb)
**Increased [[Hematocrit]] (Hct)
**Increased [[blood urea nitrogen]] (BUN)
**Decreased [[bicarbonate]]  
**Decreased [[creatinine]] (Cr)  
**Decreased [[PCO2]]


==References==
==References==
{{Reflist|2}}
{{reflist|2}}


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[[Category:Mountaineering]]
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[[Category:Emergency medicine]]
[[Category:Pulmonology]]
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Latest revision as of 15:06, 21 March 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of altitude sickness include increased the level of hemoglobin, hematocrit and blood urea nitrogen and decreased level of bicarbonate, creatinine and PCO2.

Laboratory Findings

References

  1. Shah MB, Braude D, Crandall CS, Kwack H, Rabinowitz L, Cumbo TA, Basnyat B, Bhasyal G (2006). "Changes in metabolic and hematologic laboratory values with ascent to altitude and the development of acute mountain sickness in Nepalese pilgrims". Wilderness Environ Med. 17 (3): 171–7. PMID 17078312.

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