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{{Altitude sickness}}
{{Altitude sickness}}
{{CMG}}
{{CMG}} {{AE}} {{F.K}}


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Revision as of 20:25, 2 March 2018

Altitude sickness Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

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Overview

Chronic mountain sickness (CMS) is characterized by polycythemia (increased hematocrit) and hypoxemia which both decrease on descent from altitude. CMS is believed to arise because of an excessive production of red blood cells, which increases the oxygen carrying capacity of the blood but may cause increased blood viscosity and uneven blood flow through the lungs (V/Q mismatch). However, CMS is also considered an adaptation of pulmonary and heart disease to life under chronic hypoxia at altitude.[1] Clinical diagnosis by laboratory indicators have ranges of: Hb > 200 g/L, Hct > 65%, and arterial oxygen saturation (SaO2) < 85% in both genders.[2]

Laboratory Findings

  • Laboratory findings consistent with the diagnosis of altitude sickness include:[3]
    • Increased Hb
    • Increased Hct
    • Increased BUN
    • Decreased bicarbonate
    • Decreased creatinine
    • Decreased PCO2

References

  1. Zubieta-Castillo G, Zubieta-Calleja GR, Zubieta-Calleja L (2006). "Chronic mountain sickness: the reaction of physical disorders to chronic hypoxia". J Physiol Pharmacol. 57 Suppl 4: 431–42. PMID 17072074.
  2. West JB (2010). "English translation of "Nomenclature, classification, and diagnostic criteria of high altitude disease in China"". High Alt Med Biol. 11 (2): 169–72. doi:10.1089/ham.2010.1014. PMID 20586602.
  3. Shah MB, Braude D, Crandall CS, Kwack H, Rabinowitz L, Cumbo TA, Basnyat B, Bhasyal G (2006). "Changes in metabolic and hematologic laboratory values with ascent to altitude and the development of acute mountain sickness in Nepalese pilgrims". Wilderness Environ Med. 17 (3): 171–7. PMID 17078312.

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