View source for AlkB homolog 5, RNA demethylase

{{Infobox_gene}}

'''AlkB homolog 5, RNA demethylase''' is a [[protein]] that in humans is encoded by the ALKBH5 [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: AlkB homolog 5, RNA demethylase
| url = https://www.ncbi.nlm.nih.gov/gene/54890
| accessdate = 2017-07-27
}}</ref>



== References ==

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== Further reading ==

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*{{cite journal |vauthors=Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ |title=Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α) |journal=PLoS ONE |volume=6 |issue=1 |pages=e16210 |year=2011 |pmid=21264265 |pmc=3021549 |doi=10.1371/journal.pone.0016210 |url=}}
*{{cite journal |vauthors=Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C |title=ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility |journal=Mol. Cell |volume=49 |issue=1 |pages=18–29 |year=2013 |pmid=23177736 |pmc=3646334 |doi=10.1016/j.molcel.2012.10.015 |url=}}
*{{cite journal |vauthors=Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA |title=Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation |journal=Nucleic Acids Res. |volume=42 |issue=7 |pages=4741–54 |year=2014 |pmid=24489119 |pmc=3985658 |doi=10.1093/nar/gku085 |url=}}
*{{cite journal |vauthors=Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z |title=Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition |journal=J. Biol. Chem. |volume=289 |issue=17 |pages=11571–83 |year=2014 |pmid=24616105 |pmc=4002068 |doi=10.1074/jbc.M113.546168 |url=}}
*{{cite journal |vauthors=Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J |title=Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation |journal=J. Biol. Chem. |volume=289 |issue=25 |pages=17299–311 |year=2014 |pmid=24778178 |pmc=4067165 |doi=10.1074/jbc.M114.550350 |url=}}
*{{cite journal |vauthors=Du T, Rao S, Wu L, Ye N, Liu Z, Hu H, Xiu J, Shen Y, Xu Q |title=An association study of the m6A genes with major depressive disorder in Chinese Han population |journal=J Affect Disord |volume=183 |issue= |pages=279–86 |year=2015 |pmid=26047305 |doi=10.1016/j.jad.2015.05.025 |url=}}
*{{cite journal |vauthors=Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL |title=Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=113 |issue=14 |pages=E2047–56 |year=2016 |pmid=27001847 |pmc=4833258 |doi=10.1073/pnas.1602883113 |url=}}

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