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__NOTOC__
__NOTOC__
{{Adult T-cell leukemia}}
{{Adult T-cell leukemia}}
{{CMG}} {{AE}} {{HL}}  
{{CMG}}; {{AE}} {{HL}}, {{AIDA}}; {{GRR}} {{Nat}}  


==Overview==
==Overview==
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==Classification==
==Classification==
* Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an [[acute]] variant, [[chronic]] variant, smouldering variant, or an adult T-cell [[lymphoma]] variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693  }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370  }} </ref>
* Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an [[acute]] variant, [[chronic]] variant, smoldering variant, or an adult T-cell [[lymphoma]] variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693  }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370  }} </ref>
* The table below lists the adult T-cell leukemia clinical classification details:
* The table below lists the adult T-cell leukemia clinical classification details:


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! style="background: #4479BA; width: 600px; color: #FFFFFF;" |Description
! style="background: #4479BA; width: 600px; color: #FFFFFF;" |Description
|-
|-
! align="center" style="background:#DCDCDC;" |Acute adult T-cell leukemia<ref name="pmid19064971">{{cite journal |vauthors=Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T |title=Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting |journal=J. Clin. Oncol. |volume=27 |issue=3 |pages=453–9 |date=January 2009 |pmid=19064971 |pmc=2737379 |doi=10.1200/JCO.2008.18.2428 |url=}}</ref>
! style="background:#DCDCDC;" align="center" |Acute adult T-cell leukemia<ref name="pmid19064971">{{cite journal |vauthors=Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T |title=Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting |journal=J. Clin. Oncol. |volume=27 |issue=3 |pages=453–9 |date=January 2009 |pmid=19064971 |pmc=2737379 |doi=10.1200/JCO.2008.18.2428 |url=}}</ref>
| align="left" style="background:#F5F5F5;" |  
| style="background:#F5F5F5;" align="left" |  
* Leukemic clinical presentation   
* Leukemic clinical presentation   
* [[Organomegaly]] present  
* [[Organomegaly]] present  
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* [[Hypercalcaemia]]
* [[Hypercalcaemia]]
|-
|-
! align="center" style="background:#DCDCDC;" |[[Chronic adult T-cell leukemia]]
! style="background:#DCDCDC;" align="center" |Chronic adult T-cell leukemia
| align="left" style="background:#F5F5F5;" |  
| style="background:#F5F5F5;" align="left" |  
* [[Lymphocyte]] count greater than 4×10<sup>9</sup>/L  
* [[Lymphocyte]] count greater than 4×10<sup>9</sup>/L  
* [[Cutaneous]], [[pulmonary]], and [[hepatic]] involvement  
* [[Cutaneous]], [[pulmonary]], and [[hepatic]] involvement  
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* Normal [[serum]] [[calcium]] level  
* Normal [[serum]] [[calcium]] level  
|-
|-
! align="center" style="background:#DCDCDC;" |[[Primary cutaneous tumoral (PCT)]]
! style="background:#DCDCDC;" align="center" |Primary cutaneous tumoral (PCT)
| align="left" style="background:#F5F5F5;" |  
| style="background:#F5F5F5;" align="left" |  
* [[Cutaneous]] involvement. Nodules on the skin.
* [[Cutaneous]] involvement; nodules on the skin  
* Poor prognosis.  
* Poor prognosis.  
* Normal [[serum]] [[LDH]] level (or less that twice the normal upper limit)
* Normal [[serum]] [[LDH]] level (or less that twice the normal upper limit)
* Normal [[serum]] [[calcium]] level  
* Normal [[serum]] [[calcium]] level  
|-
|-
! align="center" style="background:#DCDCDC;" |Smoldering adult T-cell leukemia <ref name="pmid18042693">{{cite journal |vauthors=Matutes E |title=Adult T-cell leukaemia/lymphoma |journal=J. Clin. Pathol. |volume=60 |issue=12 |pages=1373–7 |date=December 2007 |pmid=18042693 |pmc=2095573 |doi=10.1136/jcp.2007.052456 |url=}}</ref>
! style="background:#DCDCDC;" align="center" |Smoldering adult T-cell leukemia<ref name="pmid18042693">{{cite journal |vauthors=Matutes E |title=Adult T-cell leukaemia/lymphoma |journal=J. Clin. Pathol. |volume=60 |issue=12 |pages=1373–7 |date=December 2007 |pmid=18042693 |pmc=2095573 |doi=10.1136/jcp.2007.052456 |url=}}</ref>
| align="left" style="background:#F5F5F5;" |  
| style="background:#F5F5F5;" align="left" |  
* [[Cutaneous]] and/or [[pulmonary]] infiltrates
* [[Cutaneous]] and/or [[pulmonary]] infiltrates
* No other organ involvement
* No other organ involvement
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* Normal serum [[calcium]] level  
* Normal serum [[calcium]] level  
|-
|-
! align="center" style="background:#DCDCDC;" |Adult T-cell lymphoma
! style="background:#DCDCDC;" align="center" |Adult T-cell lymphoma<ref name="pmid27925051">{{cite journal |vauthors=Oliveira PD, Farre L, Bittencourt AL |title=Adult T-cell leukemia/lymphoma |journal=Rev Assoc Med Bras (1992) |volume=62 |issue=7 |pages=691–700 |date=October 2016 |pmid=27925051 |doi=10.1590/1806-9282.62.07.691 |url=}}</ref>
| align="left" style="background:#F5F5F5;" |  
| style="background:#F5F5F5;" align="left" |  
* [[Organomegaly]] present
* [[Organomegaly]] present
* Less than 1% leukemic cells in the [[circulation]]
* Less than 1% leukemic cells in the [[circulation]]
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Medicine]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Hematology]]
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[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Up-To-Date]]
[[Category:Up-To-Date]]
[[Category:Primary care]]

Latest revision as of 20:18, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2], Aida Javanbakht, M.D.; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smoldering variant, or an adult T-cell lymphoma variant.

Classification

  • Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smoldering variant, or an adult T-cell lymphoma variant.[1][2]
  • The table below lists the adult T-cell leukemia clinical classification details:
Clinical Variant Description
Acute adult T-cell leukemia[3]
Chronic adult T-cell leukemia
Primary cutaneous tumoral (PCT)
  • Cutaneous involvement; nodules on the skin
  • Poor prognosis.
  • Normal serum LDH level (or less that twice the normal upper limit)
  • Normal serum calcium level
Smoldering adult T-cell leukemia[1]
Adult T-cell lymphoma[4]

References

  1. 1.0 1.1 Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
  2. Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.
  3. Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T (January 2009). "Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting". J. Clin. Oncol. 27 (3): 453–9. doi:10.1200/JCO.2008.18.2428. PMC 2737379. PMID 19064971.
  4. Oliveira PD, Farre L, Bittencourt AL (October 2016). "Adult T-cell leukemia/lymphoma". Rev Assoc Med Bras (1992). 62 (7): 691–700. doi:10.1590/1806-9282.62.07.691. PMID 27925051.