Adult-onset Still's disease natural history, complications and prognosis: Difference between revisions
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=== Life threatening complications === | === Life threatening complications === | ||
Adult-onset Still's disease may lead to the development of the following life-threatening complications:<ref name="pmid24435354">{{cite journal |vauthors=Efthimiou P, Kadavath S, Mehta B |title=Life-threatening complications of adult-onset Still's disease |journal=Clin. Rheumatol. |volume=33 |issue=3 |pages=305–14 |date=March 2014 |pmid=24435354 |doi=10.1007/s10067-014-2487-4 |url=}}</ref> | Adult-onset Still's disease may lead to the development of the following life-threatening complications:<ref name="pmid24435354">{{cite journal |vauthors=Efthimiou P, Kadavath S, Mehta B |title=Life-threatening complications of adult-onset Still's disease |journal=Clin. Rheumatol. |volume=33 |issue=3 |pages=305–14 |date=March 2014 |pmid=24435354 |doi=10.1007/s10067-014-2487-4 |url=}}</ref><ref name="pmid2351497">{{cite journal |vauthors=Sachs RN, Talvard O, Lanfranchi J |title=Myocarditis in adult Still's disease |journal=Int. J. Cardiol. |volume=27 |issue=3 |pages=377–80 |date=June 1990 |pmid=2351497 |doi= |url=}}</ref> | ||
* Macrophage activation syndrome (MAS) | * Macrophage activation syndrome (MAS) | ||
* Disseminated intravascular coagulation (DIC) | * Disseminated intravascular coagulation (DIC) | ||
| Line 25: | Line 25: | ||
* Diffuse alveolar hemmorrhage | * Diffuse alveolar hemmorrhage | ||
* Pulmonary arterial hypertension (PAH) | * Pulmonary arterial hypertension (PAH) | ||
* Pericardial tamponade | |||
* Myocarditis | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 14:31, 17 April 2018
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Adult-onset Still's disease |
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Differentiating Adult-onset Still’s Disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Natural History
- If left untreated, adult-onset Still's disease (AOSD) follows a relapsing and remitting course.
- Initial presentation of AOSD may be between 16 to 35 years of age.
- Symptoms usually evolve over weeks to months.
- AOSD exhibits a variable clinical course:
- 20% with long-term remission
- 30% remit-relapse
- 50% chronic arthritis
- May progress to develop macrophage activating syndrome (MAS), also known as hemophagocytic syndrome.
Complications
Life threatening complications
Adult-onset Still's disease may lead to the development of the following life-threatening complications:[1][2]
- Macrophage activation syndrome (MAS)
- Disseminated intravascular coagulation (DIC)
- Thrombotic thrombocytopenic purpura (TTP)
- Diffuse alveolar hemmorrhage
- Pulmonary arterial hypertension (PAH)
- Pericardial tamponade
- Myocarditis
Prognosis
References
- ↑ Efthimiou P, Kadavath S, Mehta B (March 2014). "Life-threatening complications of adult-onset Still's disease". Clin. Rheumatol. 33 (3): 305–14. doi:10.1007/s10067-014-2487-4. PMID 24435354.
- ↑ Sachs RN, Talvard O, Lanfranchi J (June 1990). "Myocarditis in adult Still's disease". Int. J. Cardiol. 27 (3): 377–80. PMID 2351497.