Adult-onset Still's disease natural history, complications and prognosis

Adult-onset Still's disease
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Natural History

• If left untreated, adult-onset Still's disease (AOSD) follows a relapsing and remitting course.
• Initial presentation of AOSD may be between 16 to 35 years of age.
• Symptoms usually evolve over weeks to months.
• AOSD exhibits a variable clinical course:
  • 20% with long-term remission
  • 30% remit-relapse
  • 50% chronic arthritis
• May progress to develop macrophage activating syndrome (MAS), also known as hemophagocytic syndrome.