Adult-onset Still's disease classification

Revision as of 23:13, 7 April 2018 by Skazmi (talk | contribs)
Jump to navigation Jump to search


Template:Adult-onset Still's disease Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

Classification based on clinical presentation

Adult-onset Stiil's disease (AOSD) may be classified based on the predominant clinical picture with which the patient presents. The following are the sub-types:[1]

  • ASOD with pre-dominant systemic symptoms
  • ASOD with pre-dominant arthritis
Adult-onset Still's disease sub-types Systemic sub-type Distinguishing features
Pre-dominant cellular mechanism Clinical presentation Cytokine profile Response to treatment Miscellaneous
  • Natural killer (NK) cell dysfunction (deficiency)
  • CD8 type (cytotoxic) T cell dysfunction (deficiency)
Arthritis sub-type

References

  1. Villanueva J, Lee S, Giannini EH, Graham TB, Passo MH, Filipovich A, Grom AA (2005). "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome". Arthritis Res. Ther. 7 (1): R30–7. doi:10.1186/ar1453. PMC 1064882. PMID 15642140.