Adipokine
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Template:Mergeto The adipokines or adipocytokines are a group of cytokines (cell-to-cell signalling proteins) secreted by adipose tissue.
Members include:
- adiponectin
- chemerin[1]
- interleukin-6 (IL-6)[2]
- leptin (Ob ligand)
- plasminogen activator inhibitor-1 (PAI-1)
- resistin
- retinol binding protein 4 (RBP4)
- tumor necrosis factor-alpha (TNFα)
- visfatin
Their relative roles in modifying appetite, insulin resistance and atherosclerosis are the subjects of intense research, as they may be modifyable causes of morbidity in people with obesity.[3][4]
Notes
- ↑ MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161
- ↑ Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054
- ↑ Matsuzawa, Yuji; Funahashi, Tohru and Nakamura, Tadashi (1999) "Molecular Mechanism of Metabolic Syndrome X: Contribution of Adipocytokines - Adipocyte-derived Bioactive Substances" Annals of the New York Academy of Sciences 892: pp. 146-54 Abstract
- ↑ Funahashi, T. et al. (1999) "Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity" Internal Medicine (Japan) 38: pp. 202-206 Abstract
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