Acyl CoA dehydrogenase

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Acyl CoA dehydrogenase is the enzyme used to catalyze the first step of β-oxidation in Fatty acid metabolism.


The following reaction is the oxidation of the fatty acid by FAD.


The enzyme catalyzes the formation of a double bond between the C-2 and C-3. The end product is trans-Δ2-enoyl-CoA.

It is classified as EC


It is made up of the following proteins:

Several of the units are classified by length, and some of those are associated with a particular metabolic disorder:

Unit Chain Disorder
ACADVL very long chain Very long-chain acyl-coenzyme A dehydrogenase deficiency ("VLCAD")
ACADL long chain -
ACADM C-4 to C-12 straight chain (medium chain) Medium-chain acyl-coenzyme A dehydrogenase deficiency ("MCAD")
ACADS C-2 to C-3 short chain Short-chain acyl-coenzyme A dehydrogenase deficiency ("SCAD")
ACADSB short/branched chain -

Other subunits include ACAD8, ACAD9, ACAD10 and ACAD11.

See also

External links