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{{Acute diarrhea}}
{{Acute diarrhea}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{Cherry}}
==Overview==
==Overview==
There is no established system for the classification of [disease name].
Diarrhea is defined as the passage of unformed or abnormally fluid [[Human feces|stools]] at an increased frequency. Acute diarrhea has a duration of < 4 weeks and may be classified on the basis of [[etiology]] and presentation. On the basis of [[etiology]], acute diarrhea may be classified into [[Infection|infectious]] and non-[[infectious]] sub-types. Based on the type of presentation, acute diarrhea may be classified into watery and [[inflammatory]] types. Watery diarrhea may be further classified into secretory and osmotic types of diarrhea.
 
OR
 
[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
 
OR
 
[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3].
[Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
 
OR
 
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
 
OR
 
If the staging system involves specific and characteristic findings and features:
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
 
OR
 
The staging of [malignancy name] is based on the [staging system].
 
OR
 
There is no established system for the staging of [malignancy name].


==Classification==
==Classification==
==Classification==
There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.
===Secretory Diarrhea===
Secretory diarrhea means that there is an increase in the active secretion, or there is an inhibition of absorption. There is little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions. Therefore, to maintain a charge balance in the lumen, [[sodium]] is carried with it, along with water.
===Osmotic Diarrhea===


Osmotic diarrhea occurs when there is a loss of water due to a heavy osmotic load. This can occur when there is [[maldigestion]] (e.g., pancreatic disease or [[Coeliac disease]]), where the nutrients are left in the lumen, which pulls water into the lumen.
==== Classification based on etiology ====
*Acute diarrhea may be classified according to [[etiology]] into [[infectious]] and non-[[infectious]] subtypes/groups. The [[infectious]] group may further be classified into [[Bacteria|bacterial]], [[Virus|viral]], [[Fungus|fungal]] and [[Protozoa|protozoal]] subgroups. The non-infectious group is further classified into diarrhea due to [[Medication|medications]], [[Poison|poisoning]] and systemic illnesses.
{{Family tree/start}}
{{Family tree | | | | | | | | | | | | | | | | | | | | | A01 | | | |A01= Acute diarrhea}}
{{Family tree | | | | | | | | | | | | | | | | | | | | | |!| | | | | }}
{{Family tree | | | | | | | | | | | |,|-|-|-|-|-|-|-|-|-|^|-|-|-|-|-|-|-|-|-|.| }}
{{Family tree | | | | | | | | | | | C01 | | | | | | | | | | | | | | | | | | C02 | | | |C01=Infectious |C02=Non-Infectious}}
{{Family tree | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | |!| | | |}}
{{Family tree | | | |,|-|-|-|v|-|-|-|^|-|-|v|-|-|-|.| | | | | | | |,|-|-|-|-|+|-|-|-|-|.| }} 
{{Family tree | | | C01 | | C02 | | | | | C03 | | C04 | | | | | | C05 | | | C06 | | | C07 | | | |C01=[[Bacterial]]|C02=[[Viral]]|C03=[[Fungal]]|C04=[[Protozoa]]|C05=[[Medications]]|C06=[[Poisoning]]|C07=[[Systemic illness]]}}
{{family tree | | | |!| | | |!| | | | | | |!| | | |!| | | | | | | |!| | | | |!| | | | |!| | | | |}}
{{familytree |boxstyle=text-align: left; | | | C01 | | C02 | | | | | C03 | | C04 | | | | | | C05 | | | C06 | | | C07 | | | |C01= •[[Shigella]] species ( S.dysentriae, S.flexneri, S.sonneii, S.boydii)<br>
[[E.coli]] species (Enterotoxigenic E.coli, Enterohemorrhagic E.coli, Enteroinvasive E.coli, EPEC, EAEC)<br>
•[[Cryptosporidium parvum]]<br>
•[[Vibrio cholerae]], [[Vibrio parahemolyticus]]<br>
•[[Clostridium perfringens]]<br>
•Non-Typhoidal [[Salmonella]]: S.typhimurium, S.enterica<br>
•[[Campylobacter jejuni]]<br>
•[[Clostridium difficle]]<br>
•[[Yersinia enterocolitica]]<br>
•[[Staphylococcus aureus]] (staphylococcal toxic shock syndrome [TSS]<br>
•[[Aeromonas]]<br>
•[[Plesiomonas shigelloides]]<br>
•[[Hemolytic uremic syndrome]] (Shiga toxin producing E. coli ETEC)<br>
•[[Mycobacterium Avium complex]]<br>
•[[Bacillus cereus]]<br>
•[[Listeria monocytogenes]]<br>


===Motility-Related Diarrhea===
|C02=
•[[Astro virus]]<br>
•[[Calcivirus]]<br>
•[[Noro virus]]<br>
•[[Rota virus]]<br>
•[[CMV]]<br>
•[[Norwalk virus]]<br>
•[[Influenza virus]]<br>
•[[Rubeola virus]]<br>
•[[Dengue virus]]<br>
•[[Human immunodeficiency virus]]<br>
| C03=
•[[Cryptococcus]]<br>
•[[Candida albicans]]<br>
| C04=
•[[Giardia lamblia]]<br>
•[[Microsporidia]]<br>
•[[Isospora]]<br>
|C05=  
•[[Digoxin]]<br>
•[[Cephalosporins]]<br>
•[[Thiazide diuretics]]<br>
•[[Triptans]]<br>
•[[Lactulose]]<br>
•[[Anti retroviral agents]]<br>
•[[Chemotherapeutic agents]]<br>
•[[Antifungals]]<br>
•[[Magnesium]]<br>
| C06=  
•[[Organophosphate]] Poisoning<br>
•[[Opium withdrawal]]<br>
| C07=
•[[Hyperthyroidism]]<br>
•[[Irritable bowel syndrome]]<br>
•[[Lactose intolerance]]<br>
•[[Tumors]]: [[VIPoma]]<br>
•[[Short bowel syndrome]]<br>
•[[Radiation enteritis]]<br>
}}
{{Family tree/end}}


Motility-related diarrhea occurs when the motility of the gastrointestinal tract is abnormally high. If the food moves too quickly, there is not enough time for sufficient nutrients and water to be absorbed. This can be due to a [[vagotomy]] or [[diabetic neuropathy]], or a complication of [[menstruation]].
==== Classification based on presentation ====
 
*Based on the type of presentation, acute diarrhea may be classified into watery and inflammatory types. Watery diarrhea may further be classified into secretory and osmotic types of diarrhea.
===Inflammatory Diarrhea===
{{Family tree/start}}
Inflammatory diarrhea occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. Features of all three of the other types of diarrhea can be found in this type of diarrhea. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel disease.
{{familytree | | | | | | | | | | | | | | A01 | | | | | | | | |A01= Acute diarrhea}}
 
{{familytree | | | | | | | | | | | | | | |!| | | | | | | | | |}}
===Others===
{{familytree | | | | | | | | | |,|-|-|-|-|^|-|-|-|-|.| | | |}}
* [[Infectious diarrhea]]
{{familytree | | | | | | | | | C01 | | | | | | | | C02 | | |C01= Watery |C02=Inflammatory}}
* [[Inflammatory bowel disease]]
{{family tree| | | | | | | | | |!| | | | | | | | | |!| | | | |}}
* [[Irritable bowel syndrome]]
{{familytree |boxstyle=text-align: left; | | | | |,|-|-|-|-|^|-|-|-|-|.| | | | C03 | | | |C03=
* [[Malabsorption]]
[[Crohn’s disease]] or [[ulcerative colitis]]<br>
 
[[Cytomegalovirus]]<br>
*There is no established system for the classification of [disease name].
[[Herpes simplex virus]]<br>
OR
•[[Strongyloidiasis]]<br>
*[Disease name] may be classified according to [classification method] into [number] subtypes/groups:
[[Aeromonas]]<br>
**[Group1]
•[[Plesiomonas]]<br>
**[Group2]
•[[Ischemic colitis]]<br>
**[Group3]
•[[Radiation colitis]]}}
**[Group4]
{{family tree| | | | C01 | | | | | | | | C02 | | | | | | | |C01= Secretory| C02= Osmotic}}
OR
{{family tree| | | | |!| | | | | | | | | |!| | | | | | | | |}}
*[Disease name] may be classified into [large number > 6] subtypes based on:
{{familytree |boxstyle=text-align: left; | | | | C01 | | | | | | | | C02 | | | | | | | | C01= •Cholera<br>
**[Classification method 1]
•Enterotoxigenic strains of [[E. coli]]<br>
**[Classification method 2]
•Factitious diarrhea from [[laxative abuse]]<br>
**[Classification method 3]
•[[Aeromonas]]<br>
*[Disease name] may be classified into several subtypes based on:
•[[Plesiomonas]]<br>
**[Classification method 1]
•[[Microsporidia]]<br>
**[Classification method 2]
•[[Giardia]]<br>
**[Classification method 3]
•[[Coccidia]]<br>
OR
•[[Cryptosporidium]]
*Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
| C02=
OR
[[Lactase deficiency]]<br>
*If the staging system involves specific and characteristic findings and features:
[[Lactulose]]<br>
*According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
[[Laxative abuse]]<br>
OR
[[Whipple's disease]]}}
*The staging of [malignancy name] is based on the [staging system].
{{Family tree/end}}
OR
*There is no established system for the staging of [malignancy name].


==References==
==References==
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[[Category: (name of the system)]]
 
[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Up-To-Date]]

Latest revision as of 20:15, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sudarshana Datta, MD [2]

Overview

Diarrhea is defined as the passage of unformed or abnormally fluid stools at an increased frequency. Acute diarrhea has a duration of < 4 weeks and may be classified on the basis of etiology and presentation. On the basis of etiology, acute diarrhea may be classified into infectious and non-infectious sub-types. Based on the type of presentation, acute diarrhea may be classified into watery and inflammatory types. Watery diarrhea may be further classified into secretory and osmotic types of diarrhea.

Classification

Classification based on etiology

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute diarrhea
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Infectious
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Non-Infectious
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bacterial
 
Viral
 
 
 
 
Fungal
 
Protozoa
 
 
 
 
 
Medications
 
 
Poisoning
 
 
Systemic illness
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Shigella species ( S.dysentriae, S.flexneri, S.sonneii, S.boydii)

E.coli species (Enterotoxigenic E.coli, Enterohemorrhagic E.coli, Enteroinvasive E.coli, EPEC, EAEC)
Cryptosporidium parvum
Vibrio cholerae, Vibrio parahemolyticus
Clostridium perfringens
•Non-Typhoidal Salmonella: S.typhimurium, S.enterica
Campylobacter jejuni
Clostridium difficle
Yersinia enterocolitica
Staphylococcus aureus (staphylococcal toxic shock syndrome [TSS]
Aeromonas
Plesiomonas shigelloides
Hemolytic uremic syndrome (Shiga toxin producing E. coli ETEC)
Mycobacterium Avium complex
Bacillus cereus

Listeria monocytogenes
 
Astro virus

Calcivirus
Noro virus
Rota virus
CMV
Norwalk virus
Influenza virus
Rubeola virus
Dengue virus

Human immunodeficiency virus
 
 
 
 
Cryptococcus
Candida albicans
 
Giardia lamblia

Microsporidia

Isospora
 
 
 
 
 
Digoxin

Cephalosporins
Thiazide diuretics
Triptans
Lactulose
Anti retroviral agents
Chemotherapeutic agents
Antifungals

Magnesium
 
 
Organophosphate Poisoning
Opium withdrawal
 
 
Hyperthyroidism

Irritable bowel syndrome
Lactose intolerance
Tumors: VIPoma
Short bowel syndrome

Radiation enteritis
 
 
 

Classification based on presentation

  • Based on the type of presentation, acute diarrhea may be classified into watery and inflammatory types. Watery diarrhea may further be classified into secretory and osmotic types of diarrhea.
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute diarrhea
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Watery
 
 
 
 
 
 
 
Inflammatory
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Crohn’s disease or ulcerative colitis

Cytomegalovirus
Herpes simplex virus
Strongyloidiasis
Aeromonas
Plesiomonas
Ischemic colitis

Radiation colitis
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Secretory
 
 
 
 
 
 
 
Osmotic
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
•Cholera

•Enterotoxigenic strains of E. coli
•Factitious diarrhea from laxative abuse
Aeromonas
Plesiomonas
Microsporidia
Giardia
Coccidia

Cryptosporidium
 
 
 
 
 
 
 
Lactase deficiency

Lactulose
Laxative abuse

Whipple's disease
 
 
 
 
 
 
 

References

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