Acoustic neuroma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Acoustic neuromas are more common in adults, and rarely occur in children. The causes of acoustic neuromas are largely unknown. Relatively few studies have addressed this specific tumor type, as acoustic neuromas are seldom analyzed separately in risk factor analyses and are more often grouped under the general heading of brain tumors.[1]Ionizing radiation exposure is the only well-established exogenous risk factor for acoustic neuroma and has been confirmed in studies of radiation treatments and dental X-rays.[2][3]Individuals who underwent radiation treatment of tinea capitis during childhood were found to develop an excess of benign and malignant brain tumors of various histological types, including acoustic neuromas[4] [5] In addition, a study of atomic bomb survivors found that the intracranial tumor subtype most strongly related to ionizing radiation exposure was acoustic neuroma [6] [7]. A statistically significant dose-related excess of nervous system tumors, including schwannomas was observed in the cohort of atomic bomb survivors[8]. The excess relative risk per sievert (Sv) of absorbed dose for schwannomas was 4.5 (95 percent confidence interval: 1.9, 9.2) and the dose-response relationship was linear. Exposure to even moderate doses (i.e. <1 Sv) of radiation was associated with an elevated incidence of nervous system tumors, including Schwannomas.
References
- ↑ Forssén UM, Lönn S, Ahlbom A, Savitz DA, Feychting M (2006). "Occupational magnetic field exposure and the risk of acoustic neuroma". Am. J. Ind. Med. 49 (2): 112–8. doi:10.1002/ajim.20251. PMID 16374820. Unknown parameter
|month=ignored (help) - ↑ Preston DL, Ron E, Yonehara S; et al. (2002). "Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure". J. Natl. Cancer Inst. 94 (20): 1555–63. PMID 12381708. Unknown parameter
|month=ignored (help) - ↑ Ron E, Modan B, Boice JD; et al. (1988). "Tumors of the brain and nervous system after radiotherapy in childhood". N. Engl. J. Med. 319 (16): 1033–9. doi:10.1056/NEJM198810203191601. PMID 3173432. Unknown parameter
|month=ignored (help) - ↑ Edwards CG, Schwartzbaum JA, Lönn S, Ahlbom A, Feychting M (2006). "Exposure to loud noise and risk of acoustic neuroma". Am. J. Epidemiol. 163 (4): 327–33. doi:10.1093/aje/kwj044. PMID 16357108. Unknown parameter
|month=ignored (help) - ↑ Ron E, Modan B, Boice JD; et al. (1988). "Tumors of the brain and nervous system after radiotherapy in childhood". N. Engl. J. Med. 319 (16): 1033–9. doi:10.1056/NEJM198810203191601. PMID 3173432. Unknown parameter
|month=ignored (help) - ↑ Preston DL, Ron E, Yonehara S; et al. (2002). "Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure". J. Natl. Cancer Inst. 94 (20): 1555–63. PMID 12381708. Unknown parameter
|month=ignored (help) - ↑ Ron E, Modan B, Boice JD; et al. (1988). "Tumors of the brain and nervous system after radiotherapy in childhood". N. Engl. J. Med. 319 (16): 1033–9. doi:10.1056/NEJM198810203191601. PMID 3173432. Unknown parameter
|month=ignored (help) - ↑ Preston DL, Ron E, Yonehara S; et al. (2002). "Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure". J. Natl. Cancer Inst. 94 (20): 1555–63. PMID 12381708. Unknown parameter
|month=ignored (help)
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