Acoustic neuroma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The true incidence of Acoustic neuromas has been difficult to estimate.[1] [2] The incidence has been reported to range from 1 to 20 per million per year.[3] [4] [5] A study of acoustic neuromas in a review of 24,000 brain MRIs reported a prevalence of 0.07%. When comparing the clinical incidence of acoustic neuromas to the prevalence of occult acoustic neuromas ascertained from histopathological studies of temporal bones, it can be concluded that the vast majority of tumors that exist are never clinically manifested.[6] [7] Acoustic neuromas are most commonly diagnosed between the ages of 30 and 68.[8] [9] Reported cases of acoustic neuroma in childhood are rare and in such patients other evidence of NF2 should be investigated. In a study of 146 cases of acoustic neuromas, the median age of cases was 52 years.[10] In a second study of 793 cases of Acoustic neuroma, the median age of the cases was 54 years. The sex ratio (females/males) for acoustic neuromas has been reported to be >1 [11] [12] [13] [14]


Average annual incidence rates, overall and by gender and race, CBTRUS (1995–1999) and LACCSP (1995–1998)
Gender
Race
Type of Tumor Total Number of Tumors (N) Overall Rate (CI) Male Female White Nonwhite
CBTRUS, 1995–1999
Nerve sheath 2,811 1.08 (1.04–1.12) 1.10 (1.04–1.16) 1.07 (1.02–1.13) 1.13 (1.08–1.17) 0.56 (0.48–0.63)
Vestibular schwannoma 1,424 0.55 (0.52–0.58) 0.56 (0.52–0.60) 0.55 (0.51–0.58) 0.58 (0.55–0.61) 0.23 (0.18–0.28)
LACCSP, 1995–1998
Nerve sheath 352 1.11 (0.99–1.22) 1.15 (0.97–1.32) 1.07 (0.91–1.23) 1.21 (1.08–1.36) 0.68 (0.50–0.87)
Vestibular schwannoma 256 0.82 (0.71–0.92) 0.83 (0.68–0.99) (0.66–0.94)0.80 0.89 (0.77–1.01) 0.51 (0.36–0.67)
Rates are per 100,000 person-years and are age adjusted to the year 2000 U.S. standard population.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; CI, confidence interval; LACCSP, Los Angeles County Cancer Surveillance Program.

References

  1. Ho SY, Kveton JF. Acoustic neuroma assessment and management. Otolaryngol Clin North Am 2002;35:393-404
  2. Tos M, Charabi S, Thomsen J. Clincial experience with vestibular schwannomas: epidemiology, symptomatology, diagnosis, and surgical results. Eur Arch Otorhinolaryngol 1998;255:1-6.
  3. Howitz MF, Johansen C, Tos M, Charabi S, Olsen JH. Incidence of Vestibular Schwannoma in Denmark, 1977-1995. Am J Otol 2000;21:690-694
  4. Tos M, Charabi S, Thomsen J. Clincial experience with vestibular schwannomas: epidemiology, symptomatology, diagnosis, and surgical results. Eur Arch Otorhinolaryngol 1998;255:1-6.
  5. Tos M, Stangerup SE, Cayé-Thomasen P, Tos T, Thomsen J. What is the real incidence of vestibular schwannoma? Arch Otolaryngol Head Neck Surg 2004;130:216-220
  6. Thomsen J, Tos M. Acoustic neuroma: clinical aspects, audiovestibular assessment, diagnostic delay, and growth rate. Am J Otol 1990;11:12-19.
  7. Rosenberg SI. Natural history of acoustic neuromas. Laryngoscope 2000;110:497-508.
  8. Strasnick B, Glasscock ME, Haynes D, McMenomey SO, Minor LB. The natural history of untreated acoustic neuromas. Laryngoscope1994;104:1115-1119.
  9. Hart RG, Davenport J. Diagnosis of acoustic neuroma. Neurosurgery 1981;9:450-463.
  10. Edwards CG, Schwartzbaum JA, Lönn S, Ahlbom A, Feychting M. Exposure to loud noise and risk of acoustic neuroma. Am J Epidemiol 2006;163:327-333.
  11. Inskip PD, Tarone RE, Hatch EE, et al. Sociodemographic indicators and risk of brain tumours. Int J Epidemiol 2003;32:225-233.
  12. Howitz MF, Johansen C, Tos M, Charabi S, Olsen JH. Incidence of Vestibular Schwannoma in Denmark, 1977-1995. Am J Otol 2000;21:690-694.
  13. Chandler CL, Ramsden RT. Acoustic schwannoma. Br J Hosp Med 1993;49:336-343.
  14. Spoelhof GD. When to suspect acoustic neuroma. Am Fam Physician 1995;52:1768-1774.

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