Abderhalden reaction: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
 
(3 intermediate revisions by one other user not shown)
Line 1: Line 1:
{{SI}}
The '''Abderhalden reaction''' is a now [[Wiktionary:Defunct|defunct]] [[blood test]] for [[pregnancy]] developed by [[Emil Abderhalden]].
The '''Abderhalden reaction''' is a now [[Wiktionary:Defunct|defunct]] [[blood test]] for [[pregnancy]] developed by [[Emil Abderhalden]].


In 1909 [[Emil Abderhalden|Abderhalden]] found that on identification of a foreign protein in the blood, the body reacts with a "defensive fermentation" (in modern terms, a [[protease]] reaction) that causes disintegration of the protein. He developed the test in 1912.  This test was apparently contentious soon after its development and a significant body of work was published both in support of and refuting the test's reliability.  One such publication concluded "...the individual variations of both pregnant and non-pregnant sera make the results from both overlap so completely as to render the reaction, even with quantitative technique, absolutely indecisive for either positive or negative diagnosis of pregnancy." (Van Slyke ''et al.'' 1915). The test's overall unreliability led to its being superseded in 1928 by the [[Ascheim-Zondek test]]. Due to Abderhalden's high reputation, it was not internationally acknowledged until long after his death that the underlying theory of "defensive enzymes" (''Abwehrfermente'') was entirely fraudulent (Deichmann & Müller-Hill 1998).
In 1909 [[Emil Abderhalden|Abderhalden]] found that on identification of a foreign protein in the blood, the body reacts with a "defensive fermentation" (in modern terms, a [[protease]] reaction) that causes disintegration of the protein. He developed the test in 1912.  This test was apparently contentious soon after its development and a significant body of work was published both in support of and refuting the test's reliability.  One such publication concluded "...the individual variations of both pregnant and non-pregnant sera make the results from both overlap so completely as to render the reaction, even with quantitative technique, absolutely indecisive for either positive or negative diagnosis of pregnancy." (Van Slyke ''et al.'' 1915). The test's overall unreliability led to its being superseded in 1928 by the [[Aschheim-Zondek test]]. Due to Abderhalden's high reputation, it was not internationally acknowledged until long after his death that the underlying theory of "defensive enzymes" (''Abwehrfermente'') was entirely fraudulent (Deichmann & Müller-Hill 1998).


==References==
==References==
Line 8: Line 11:
* Van Slyke, Donald D.; Vinograd-Villchur, Mariam; and Losee, J.R. (1915): The Abderhalden Reaction. ''[[Journal of Biological Chemistry]]'' '''23'''(1):377-406. [http://www.jbc.org/cgi/reprint/23/1/377.pdf  PDF fulltext] <small>experimental evidence of the unreliability of the Abderhalden pregnancy test</small>
* Van Slyke, Donald D.; Vinograd-Villchur, Mariam; and Losee, J.R. (1915): The Abderhalden Reaction. ''[[Journal of Biological Chemistry]]'' '''23'''(1):377-406. [http://www.jbc.org/cgi/reprint/23/1/377.pdf  PDF fulltext] <small>experimental evidence of the unreliability of the Abderhalden pregnancy test</small>
* [http://www.whonamedit.com/synd.cfm/55.html Who Named It?]
* [http://www.whonamedit.com/synd.cfm/55.html Who Named It?]
{{med-stub}}
 
{{WikiDoc Sources}}
{{WikiDoc Sources}}
{{WH}}
{{WS}}

Latest revision as of 19:28, 8 August 2012

WikiDoc Resources for Abderhalden reaction

Articles

Most recent articles on Abderhalden reaction

Most cited articles on Abderhalden reaction

Review articles on Abderhalden reaction

Articles on Abderhalden reaction in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Abderhalden reaction

Images of Abderhalden reaction

Photos of Abderhalden reaction

Podcasts & MP3s on Abderhalden reaction

Videos on Abderhalden reaction

Evidence Based Medicine

Cochrane Collaboration on Abderhalden reaction

Bandolier on Abderhalden reaction

TRIP on Abderhalden reaction

Clinical Trials

Ongoing Trials on Abderhalden reaction at Clinical Trials.gov

Trial results on Abderhalden reaction

Clinical Trials on Abderhalden reaction at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Abderhalden reaction

NICE Guidance on Abderhalden reaction

NHS PRODIGY Guidance

FDA on Abderhalden reaction

CDC on Abderhalden reaction

Books

Books on Abderhalden reaction

News

Abderhalden reaction in the news

Be alerted to news on Abderhalden reaction

News trends on Abderhalden reaction

Commentary

Blogs on Abderhalden reaction

Definitions

Definitions of Abderhalden reaction

Patient Resources / Community

Patient resources on Abderhalden reaction

Discussion groups on Abderhalden reaction

Patient Handouts on Abderhalden reaction

Directions to Hospitals Treating Abderhalden reaction

Risk calculators and risk factors for Abderhalden reaction

Healthcare Provider Resources

Symptoms of Abderhalden reaction

Causes & Risk Factors for Abderhalden reaction

Diagnostic studies for Abderhalden reaction

Treatment of Abderhalden reaction

Continuing Medical Education (CME)

CME Programs on Abderhalden reaction

International

Abderhalden reaction en Espanol

Abderhalden reaction en Francais

Business

Abderhalden reaction in the Marketplace

Patents on Abderhalden reaction

Experimental / Informatics

List of terms related to Abderhalden reaction


The Abderhalden reaction is a now defunct blood test for pregnancy developed by Emil Abderhalden.

In 1909 Abderhalden found that on identification of a foreign protein in the blood, the body reacts with a "defensive fermentation" (in modern terms, a protease reaction) that causes disintegration of the protein. He developed the test in 1912. This test was apparently contentious soon after its development and a significant body of work was published both in support of and refuting the test's reliability. One such publication concluded "...the individual variations of both pregnant and non-pregnant sera make the results from both overlap so completely as to render the reaction, even with quantitative technique, absolutely indecisive for either positive or negative diagnosis of pregnancy." (Van Slyke et al. 1915). The test's overall unreliability led to its being superseded in 1928 by the Aschheim-Zondek test. Due to Abderhalden's high reputation, it was not internationally acknowledged until long after his death that the underlying theory of "defensive enzymes" (Abwehrfermente) was entirely fraudulent (Deichmann & Müller-Hill 1998).

References

  • Deichmann, U. & Müller-Hill, B. (1998): The fraud of Abderhalden's enzymes. Nature 393:109-111. HTML abstract
  • Firkin, B. G. & Whitworth, J. A. (1987): Dictionary of Medical Eponyms. Parthenon Publishing. ISBN 1-85070-333-7
  • Van Slyke, Donald D.; Vinograd-Villchur, Mariam; and Losee, J.R. (1915): The Abderhalden Reaction. Journal of Biological Chemistry 23(1):377-406. PDF fulltext experimental evidence of the unreliability of the Abderhalden pregnancy test
  • Who Named It?

Template:WikiDoc Sources


Template:WH Template:WS