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{{Infobox_gene}}
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'''Serine/threonine-protein kinase 13''' is an [[enzyme]] that in humans is encoded by the ''AURKC'' [[gene]].<ref name="pmid9799611">{{cite journal | vauthors = Bernard M, Sanseau P, Henry C, Couturier A, Prigent C | title = Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter | journal = Genomics | volume = 53 | issue = 3 | pages = 406–9 |date=Dec 1998 | pmid = 9799611 | pmc = | doi = 10.1006/geno.1998.5522 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AURKC aurora kinase C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6795| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Aurora kinase C
| HGNCid = 11391
| Symbol = AURKC
| AltSymbols =; AIE2; AIK3; AurC; STK13; aurora-C
| OMIM = 603495
| ECnumber =
| Homologene = 68302
| MGIid =
| GeneAtlas_image1 = PBB_GE_AURKC_211107_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0000910 |text = cytokinesis}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6795
    | Hs_Ensembl = ENSG00000105146
    | Hs_RefseqProtein = NP_001015878
    | Hs_RefseqmRNA = NM_001015878
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 62434240
    | Hs_GenLoc_end = 62438727
    | Hs_Uniprot = Q9UQB9
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Aurora kinase C''', also known as '''AURKC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AURKC aurora kinase C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6795| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: AURKC aurora kinase C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6795| accessdate = }}</ref>
| summary_text = This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AURKC}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Katayama H, Brinkley WR, Sen S |title=The Aurora kinases: role in cell transformation and tumorigenesis. |journal=Cancer Metastasis Rev. |volume=22 |issue= 4 |pages= 451-64 |year= 2004 |pmid= 12884918 |doi=  }}
*{{cite journal  | vauthors=Katayama H, Brinkley WR, Sen S |title=The Aurora kinases: role in cell transformation and tumorigenesis. |journal=Cancer Metastasis Rev. |volume=22 |issue= 4 |pages= 451–64 |year= 2004 |pmid= 12884918 |doi=10.1023/A:1023789416385  }}
*{{cite journal  | author=Bernard M, Sanseau P, Henry C, ''et al.'' |title=Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter. |journal=Genomics |volume=53 |issue= 3 |pages= 406-9 |year= 1998 |pmid= 9799611 |doi= 10.1006/geno.1998.5522 }}
*{{cite journal  | vauthors=Tseng TC, Chen SH, Hsu YP, Tang TK |title=Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. |journal=DNA Cell Biol. |volume=17 |issue= 10 |pages= 823–33 |year= 1998 |pmid= 9809744 |doi=10.1089/dna.1998.17.823 }}
*{{cite journal  | author=Tseng TC, Chen SH, Hsu YP, Tang TK |title=Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators. |journal=DNA Cell Biol. |volume=17 |issue= 10 |pages= 823-33 |year= 1998 |pmid= 9809744 |doi=  }}
*{{cite journal  | vauthors=Kimura M, Matsuda Y, Yoshioka T, Okano Y |title=Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7334–40 |year= 1999 |pmid= 10066797 |doi=10.1074/jbc.274.11.7334 }}
*{{cite journal  | author=Kimura M, Matsuda Y, Yoshioka T, Okano Y |title=Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7334-40 |year= 1999 |pmid= 10066797 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Clark AG, Glanowski S, Nielsen R |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 |display-authors=etal}}
*{{cite journal  | author=Clark AG, Glanowski S, Nielsen R, ''et al.'' |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960-3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 }}
*{{cite journal  | vauthors=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |display-authors=etal}}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | vauthors=Li X, Sakashita G, Matsuzaki H |title=Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47201–11 |year= 2004 |pmid= 15316025 |doi= 10.1074/jbc.M403029200 |display-authors=etal}}
*{{cite journal  | author=Li X, Sakashita G, Matsuzaki H, ''et al.'' |title=Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47201-11 |year= 2004 |pmid= 15316025 |doi= 10.1074/jbc.M403029200 }}
*{{cite journal  | vauthors=Sasai K, Katayama H, Stenoien DL |title=Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. |journal=Cell Motil. Cytoskeleton |volume=59 |issue= 4 |pages= 249–63 |year= 2005 |pmid= 15499654 |doi= 10.1002/cm.20039 |display-authors=etal}}
*{{cite journal  | author=Sasai K, Katayama H, Stenoien DL, ''et al.'' |title=Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. |journal=Cell Motil. Cytoskeleton |volume=59 |issue= 4 |pages= 249-63 |year= 2005 |pmid= 15499654 |doi= 10.1002/cm.20039 }}
*{{cite journal  | vauthors=Yan X, Wu Y, Li Q |title=Cloning and characterization of a novel human Aurora C splicing variant. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 353–61 |year= 2005 |pmid= 15670791 |doi= 10.1016/j.bbrc.2004.12.168 |display-authors=etal}}
*{{cite journal  | author=Yan X, Wu Y, Li Q, ''et al.'' |title=Cloning and characterization of a novel human Aurora C splicing variant. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 1 |pages= 353-61 |year= 2005 |pmid= 15670791 |doi= 10.1016/j.bbrc.2004.12.168 }}
*{{cite journal  | vauthors=Chen HL, Tang CJ, Chen CY, Tang TK |title=Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. |journal=J. Biomed. Sci. |volume=12 |issue= 2 |pages= 297–310 |year= 2005 |pmid= 15917996 |doi= 10.1007/s11373-005-0980-0 }}
*{{cite journal  | author=Chen HL, Tang CJ, Chen CY, Tang TK |title=Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. |journal=J. Biomed. Sci. |volume=12 |issue= 2 |pages= 297-310 |year= 2005 |pmid= 15917996 |doi= 10.1007/s11373-005-0980-0 }}
*{{cite journal  | vauthors=Yan X, Cao L, Li Q |title=Aurora C is directly associated with Survivin and required for cytokinesis. |journal=Genes Cells |volume=10 |issue= 6 |pages= 617–26 |year= 2005 |pmid= 15938719 |doi= 10.1111/j.1365-2443.2005.00863.x |display-authors=etal}}
*{{cite journal  | author=Yan X, Cao L, Li Q, ''et al.'' |title=Aurora C is directly associated with Survivin and required for cytokinesis. |journal=Genes Cells |volume=10 |issue= 6 |pages= 617-26 |year= 2005 |pmid= 15938719 |doi= 10.1111/j.1365-2443.2005.00863.x }}
*{{cite journal  | vauthors=Dutertre S, Hamard-Péron E, Cremet JY |title=The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. |journal=Cell Cycle |volume=4 |issue= 12 |pages= 1783–7 |year= 2006 |pmid= 16258285 |doi=  10.4161/cc.4.12.2172|display-authors=etal}}
*{{cite journal  | author=Dutertre S, Hamard-Péron E, Cremet JY, ''et al.'' |title=The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. |journal=Cell Cycle |volume=4 |issue= 12 |pages= 1783-7 |year= 2006 |pmid= 16258285 |doi=  }}
*{{cite journal  | vauthors=Dieterich K, Soto Rifo R, Faure AK |title=Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. |journal=Nat. Genet. |volume=39 |issue= 5 |pages= 661–5 |year=  2007|pmid= 17435757 |doi= 10.1038/ng2027 |display-authors=etal}}
*{{cite journal  | author=Dieterich K, Soto Rifo R, Faure AK, ''et al.'' |title=Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility. |journal=Nat. Genet. |volume=39 |issue= 5 |pages= 661-5 |year=  |pmid= 17435757 |doi= 10.1038/ng2027 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-19-stub}}

Revision as of 18:29, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene.[1][2]

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.[2]

References

  1. ↑ Bernard M, Sanseau P, Henry C, Couturier A, Prigent C (Dec 1998). "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter". Genomics. 53 (3): 406–9. doi:10.1006/geno.1998.5522. PMID 9799611.
  2. ↑ 2.0 2.1 "Entrez Gene: AURKC aurora kinase C".

External links

Further reading

  • Katayama H, Brinkley WR, Sen S (2004). "The Aurora kinases: role in cell transformation and tumorigenesis". Cancer Metastasis Rev. 22 (4): 451–64. doi:10.1023/A:1023789416385. PMID 12884918.
  • Tseng TC, Chen SH, Hsu YP, Tang TK (1998). "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators". DNA Cell Biol. 17 (10): 823–33. doi:10.1089/dna.1998.17.823. PMID 9809744.
  • Kimura M, Matsuda Y, Yoshioka T, Okano Y (1999). "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3". J. Biol. Chem. 274 (11): 7334–40. doi:10.1074/jbc.274.11.7334. PMID 10066797.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
  • Li X, Sakashita G, Matsuzaki H, et al. (2004). "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C". J. Biol. Chem. 279 (45): 47201–11. doi:10.1074/jbc.M403029200. PMID 15316025.
  • Sasai K, Katayama H, Stenoien DL, et al. (2005). "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells". Cell Motil. Cytoskeleton. 59 (4): 249–63. doi:10.1002/cm.20039. PMID 15499654.
  • Yan X, Wu Y, Li Q, et al. (2005). "Cloning and characterization of a novel human Aurora C splicing variant". Biochem. Biophys. Res. Commun. 328 (1): 353–61. doi:10.1016/j.bbrc.2004.12.168. PMID 15670791.
  • Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy". J. Biomed. Sci. 12 (2): 297–310. doi:10.1007/s11373-005-0980-0. PMID 15917996.
  • Yan X, Cao L, Li Q, et al. (2005). "Aurora C is directly associated with Survivin and required for cytokinesis". Genes Cells. 10 (6): 617–26. doi:10.1111/j.1365-2443.2005.00863.x. PMID 15938719.
  • Dutertre S, Hamard-Péron E, Cremet JY, et al. (2006). "The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression". Cell Cycle. 4 (12): 1783–7. doi:10.4161/cc.4.12.2172. PMID 16258285.
  • Dieterich K, Soto Rifo R, Faure AK, et al. (2007). "Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility". Nat. Genet. 39 (5): 661–5. doi:10.1038/ng2027. PMID 17435757.



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