ATP6V0B: Difference between revisions

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{{short description|Protein-coding gene in Homo sapiens}}
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'''V-type proton ATPase 21 kDa proteolipid subunit''' is an [[enzyme]] that in humans is encoded by the ''ATP6V0B'' [[gene]].<ref name="pmid9653649">{{cite journal | vauthors = Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J | title = Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F) | journal = Genomics | volume = 50 | issue = 2 | pages = 222–8 |date=Oct 1998 | pmid = 9653649 | pmc =  | doi = 10.1006/geno.1998.5310 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=533| accessdate = }}</ref>
'''V-type [[proton ATPase]] 21 kDa [[proteolipids|proteolipid]] subunit''' is an [[enzyme]] that in humans is encoded by the ''ATP6V0B'' [[gene]].<ref name="pmid9653649">{{cite journal | vauthors = Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J | title = Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F) | journal = Genomics | volume = 50 | issue = 2 | pages = 222–8 |date=Oct 1998 | pmid = 9653649 | pmc =  | doi = 10.1006/geno.1998.5310 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=533| accessdate = }}</ref>


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| summary_text = This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c<nowiki>''</nowiki>, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.<ref name="entrez"/>
| summary_text = This gene encodes a component of [[vacuolar ATPase]] (V-ATPase), a multisubunit enzyme that mediates acidification of [[eukaryote|eukaryotic]] intracellular [[organelle]]s. V-ATPase dependent organelle acidification is necessary for such intracellular processes as [[protein sorting]], [[zymogen]] activation, [[receptor-mediated endocytosis]], and [[synaptic vesicle]] [[proton gradient]] generation. V-ATPase is composed of a [[cytosol]]ic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATP [[catalysis|catalytic]] site. The V0 domain consists of five different subunits: a, c, c', c<nowiki>''</nowiki>, and d.
 
Additional [[isoform]]s of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of [[yeast]] VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.<ref name="entrez"/>
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Latest revision as of 11:02, 28 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.[1][2]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d.

Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.[2]

References

  1. ↑ Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J (Oct 1998). "Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F)". Genomics. 50 (2): 222–8. doi:10.1006/geno.1998.5310. PMID 9653649.
  2. ↑ 2.0 2.1 "Entrez Gene: ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b".

External links

Further reading



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