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The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2gene.[1][2][3]
This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3]
References
↑Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID9556572.
↑Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID11590366.
Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats". J. Am. Soc. Nephrol. 18 (6): 1789–95. doi:10.1681/ASN.2006091062. PMID17494887.
Schefe JH, Menk M, Reinemund J, et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein". Circ. Res. 99 (12): 1355–66. doi:10.1161/01.RES.0000251700.00994.0d. PMID17082479.
Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats". Kidney Int. 70 (4): 641–6. doi:10.1038/sj.ki.5001627. PMID16807542.
Burcklé CA, Jan Danser AH, Müller DN, et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats". Hypertension. 47 (3): 552–6. doi:10.1161/01.HYP.0000199912.47657.04. PMID16401765.
Huang Y, Wongamorntham S, Kasting J, et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms". Kidney Int. 69 (1): 105–13. doi:10.1038/sj.ki.5000011. PMID16374430.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet. 14 (8): 1019–27. doi:10.1093/hmg/ddi094. PMID15746149.
