ATP6AP2

ATPase, H+ transporting, lysosomal accessory protein 2
Identifiers
Symbols	ATP6AP2 ; APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; HT028; M8-9; MGC99577; MRXE; MSTP009; XMRE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38097
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ATPase, H+ transporting, lysosomal accessory protein 2, also known as ATP6AP2, is a human gene.

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.

Further reading

• Kaneshiro Y, Ichihara A, Sakoda M; et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats". J. Am. Soc. Nephrol. 18 (6): 1789–95. doi:10.1681/ASN.2006091062. PMID 17494887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schefe JH, Menk M, Reinemund J; et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein". Circ. Res. 99 (12): 1355–66. doi:10.1161/01.RES.0000251700.00994.0d. PMID 17082479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaneshiro Y, Ichihara A, Takemitsu T; et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats". Kidney Int. 70 (4): 641–6. doi:10.1038/sj.ki.5001627. PMID 16807542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burcklé CA, Jan Danser AH, Müller DN; et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats". Hypertension. 47 (3): 552–6. doi:10.1161/01.HYP.0000199912.47657.04. PMID 16401765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang Y, Wongamorntham S, Kasting J; et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms". Kidney Int. 69 (1): 105–13. doi:10.1038/sj.ki.5000011. PMID 16374430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramser J, Abidi FE, Burckle CA; et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet. 14 (8): 1019–27. doi:10.1093/hmg/ddi094. PMID 15746149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen G, Delarue F, Burcklé C; et al. (2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. PMID 12045255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol. 51 (1): 45–50. PMID 11782983.CS1 maint: Multiple names: authors list (link)
• Demirci FY, White NJ, Rigatti BW; et al. (2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol. Vis. 7: 234–9. PMID 11590366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludwig J, Kerscher S, Brandt U; et al. (1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J. Biol. Chem. 273 (18): 10939–47. PMID 9556572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)