ATP6AP2: Difference between revisions

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{{Infobox_gene}}
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The '''renin receptor''' also known as '''ATPase H(+)-transporting lysosomal accessory protein 2''', or the '''prorenin receptor''', is a [[protein]] that in humans is encoded by the ''ATP6AP2'' [[gene]].<ref name="pmid9556572">{{cite journal | vauthors = Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H | title = Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules | journal = J Biol Chem | volume = 273 | issue = 18 | pages = 10939–47 |date=Jun 1998 | pmid = 9556572 | pmc =  | doi =10.1074/jbc.273.18.10939  }}</ref><ref name="pmid11590366">{{cite journal | vauthors = Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB | title = Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4) | journal = Mol Vis | volume = 7 | issue =  | pages = 234–9 |date=Oct 2001 | pmid = 11590366 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10159| accessdate = }}</ref>
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== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
The renin receptor binds [[renin]] and prorenin. Binding of renin to this receptor induces the conversion of [[Angiotensin#Angiotensinogen|angiotensinogen]] to [[Angiotensin#Angiotensin I|angiotensin I]].<ref name="pmid12045255">{{cite journal | vauthors = Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD | title = Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin | journal = J. Clin. Invest. | volume = 109 | issue = 11 | pages = 1417–27 |date=June 2002 | pmid = 12045255 | pmc = 150992 | doi = 10.1172/JCI14276 | url = | issn = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ATPase, H+ transporting, lysosomal accessory protein 2
| HGNCid = 18305
| Symbol = ATP6AP2
| AltSymbols =; APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; HT028; M8-9; MGC99577; MRXE; MSTP009; XMRE
| OMIM = 300556
| ECnumber = 
| Homologene = 38097
| MGIid = 1917745
| GeneAtlas_image1 = PBB_GE_ATP6AP2_201443_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATP6AP2_201444_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0002003 |text = angiotensin maturation}} {{GNF_GO|id=GO:0043408 |text = regulation of MAPKKK cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10159
    | Hs_Ensembl = ENSG00000182220
    | Hs_RefseqProtein = NP_005756
    | Hs_RefseqmRNA = NM_005765
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 40325104
    | Hs_GenLoc_end = 40350833
    | Hs_Uniprot = O75787
    | Mm_EntrezGene = 70495
    | Mm_Ensembl = ENSMUSG00000031007
    | Mm_RefseqmRNA = NM_027439
    | Mm_RefseqProtein = NP_081715
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 11744830
    | Mm_GenLoc_end = 11773924
    | Mm_Uniprot = Q1XID4
  }}
}}
'''ATPase, H+ transporting, lysosomal accessory protein 2''', also known as '''ATP6AP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10159| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This protein is associated with adenosine triphosphatases ([[ATPase]]s). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.<ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10159| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kaneshiro Y, Ichihara A, Sakoda M, ''et al.'' |title=Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 6 |pages= 1789-95 |year= 2007 |pmid= 17494887 |doi= 10.1681/ASN.2006091062 }}
*{{cite journal  | vauthors=Kaneshiro Y, Ichihara A, Sakoda M |title=Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 6 |pages= 1789–95 |year= 2007 |pmid= 17494887 |doi= 10.1681/ASN.2006091062 |display-authors=etal}}
*{{cite journal  | author=Schefe JH, Menk M, Reinemund J, ''et al.'' |title=A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. |journal=Circ. Res. |volume=99 |issue= 12 |pages= 1355-66 |year= 2007 |pmid= 17082479 |doi= 10.1161/01.RES.0000251700.00994.0d }}
*{{cite journal  | vauthors=Schefe JH, Menk M, Reinemund J |title=A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. |journal=Circ. Res. |volume=99 |issue= 12 |pages= 1355–66 |year= 2007 |pmid= 17082479 |doi= 10.1161/01.RES.0000251700.00994.0d |display-authors=etal}}
*{{cite journal  | author=Kaneshiro Y, Ichihara A, Takemitsu T, ''et al.'' |title=Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 641-6 |year= 2006 |pmid= 16807542 |doi= 10.1038/sj.ki.5001627 }}
*{{cite journal  | vauthors=Kaneshiro Y, Ichihara A, Takemitsu T |title=Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 641–6 |year= 2006 |pmid= 16807542 |doi= 10.1038/sj.ki.5001627 |display-authors=etal}}
*{{cite journal  | author=Burcklé CA, Jan Danser AH, Müller DN, ''et al.'' |title=Elevated blood pressure and heart rate in human renin receptor transgenic rats. |journal=Hypertension |volume=47 |issue= 3 |pages= 552-6 |year= 2006 |pmid= 16401765 |doi= 10.1161/01.HYP.0000199912.47657.04 }}
*{{cite journal  | vauthors=Burcklé CA, Jan Danser AH, Müller DN |title=Elevated blood pressure and heart rate in human renin receptor transgenic rats. |journal=Hypertension |volume=47 |issue= 3 |pages= 552–6 |year= 2006 |pmid= 16401765 |doi= 10.1161/01.HYP.0000199912.47657.04 |display-authors=etal}}
*{{cite journal  | author=Huang Y, Wongamorntham S, Kasting J, ''et al.'' |title=Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. |journal=Kidney Int. |volume=69 |issue= 1 |pages= 105-13 |year= 2006 |pmid= 16374430 |doi= 10.1038/sj.ki.5000011 }}
*{{cite journal  | vauthors=Huang Y, Wongamorntham S, Kasting J |title=Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. |journal=Kidney Int. |volume=69 |issue= 1 |pages= 105–13 |year= 2006 |pmid= 16374430 |doi= 10.1038/sj.ki.5000011 |display-authors=etal}}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |display-authors=etal}}
*{{cite journal  | author=Ramser J, Abidi FE, Burckle CA, ''et al.'' |title=A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 1019-27 |year= 2005 |pmid= 15746149 |doi= 10.1093/hmg/ddi094 }}
*{{cite journal  | vauthors=Ramser J, Abidi FE, Burckle CA |title=A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 1019–27 |year= 2005 |pmid= 15746149 |doi= 10.1093/hmg/ddi094 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Nguyen G, Delarue F, Burcklé C, ''et al.'' |title=Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. |journal=J. Clin. Invest. |volume=109 |issue= 11 |pages= 1417-27 |year= 2002 |pmid= 12045255 |doi=  }}
*{{cite journal  | vauthors=Hedera P, Alvarado D, Beydoun A, Fink JK |title=Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4. |journal=Ann. Neurol. |volume=51 |issue= 1 |pages= 45–50 |year= 2002 |pmid= 11782983 |doi=10.1002/ana.10051 }}
*{{cite journal  | author=Hedera P, Alvarado D, Beydoun A, Fink JK |title=Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4. |journal=Ann. Neurol. |volume=51 |issue= 1 |pages= 45-50 |year= 2002 |pmid= 11782983 |doi= }}
*{{cite journal  | vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997  | pmc=16901 |display-authors=etal}}
*{{cite journal  | author=Demirci FY, White NJ, Rigatti BW, ''et al.'' |title=Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4). |journal=Mol. Vis. |volume=7 |issue=  |pages= 234-9 |year= 2001 |pmid= 11590366 |doi= }}
*{{cite journal  | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal | author=Ludwig J, Kerscher S, Brandt U, ''et al.'' |title=Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 10939-47 |year= 1998 |pmid= 9556572 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|ATP6AP2}}
* {{UCSC gene details|ATP6AP2}}
 
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| update_protein_box = yes
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[[Category:Transmembrane receptors]]
 
 
{{gene-X-stub}}

Latest revision as of 18:26, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[1][2][3]

Function

The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[4]

This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3]

References

  1. ↑ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
  2. ↑ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.
  3. ↑ 3.0 3.1 "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
  4. ↑ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255.

Further reading

External links


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