ATP5J2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
The ''ATP5MF'' [[gene]] <ref name="pmid9653160">{{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 8175–80 | date = Jul 1998 | pmid = 9653160 | pmc = 20949 | doi = 10.1073/pnas.95.14.8175 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP5MF ATP synthase membrane subunit f| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9551| accessdate = }}</ref> encodes the '''ATP synthase subunit f, mitochondrial''' [[enzyme]] in humans.
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
| HGNCid = 848
| Symbol = ATP5J2
| AltSymbols =; ATP5JL
| OMIM = 
| ECnumber = 
| Homologene = 3594
| MGIid = 1927558
| GeneAtlas_image1 = PBB_GE_ATP5J2_202961_s_at_tn.png
| Function = {{GNF_GO|id=GO:0015078 |text = hydrogen ion transmembrane transporter activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005753 |text = mitochondrial proton-transporting ATP synthase complex}} {{GNF_GO|id=GO:0045263 |text = proton-transporting ATP synthase complex, coupling factor F(o)}}
| Process = {{GNF_GO|id=GO:0006754 |text = ATP biosynthetic process}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0015992 |text = proton transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9551
    | Hs_Ensembl = ENSG00000160916
    | Hs_RefseqProtein = NP_001003713
    | Hs_RefseqmRNA = NM_001003713
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 98893721
    | Hs_GenLoc_end = 98901744
    | Hs_Uniprot = P56134
    | Mm_EntrezGene = 57423
    | Mm_Ensembl = ENSMUSG00000038690
    | Mm_RefseqmRNA = NM_020582
    | Mm_RefseqProtein = NP_065607
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 145437366
    | Mm_GenLoc_end = 145440773
    | Mm_Uniprot = P56135
  }}
}}
'''ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2''', also known as '''ATP5J2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP5J2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9551| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mitochondrial [[ATP synthase]] catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the [[proton channel]]. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the F0 complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes.<ref name="entrez">{{cite web | title = Entrez Gene: ATP5J2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9551| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
==External links==
* {{UCSC gene info|ATP5MF}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kinosita K, Yasuda R, Noji H | title = F1-ATPase: a highly efficient rotary ATP machine | journal = Essays in Biochemistry | volume = 35 | issue =  | pages = 3–18 | year = 2003 | pmid = 12471886 | doi =  }}
| citations =
* {{cite journal | vauthors = Oster G, Wang H | title = Rotary protein motors | journal = Trends in Cell Biology | volume = 13 | issue = 3 | pages = 114–21 | date = Mar 2003 | pmid = 12628343 | doi = 10.1016/S0962-8924(03)00004-7 }}
*{{cite journal | author=Kinosita K, Yasuda R, Noji H |title=F1-ATPase: a highly efficient rotary ATP machine. |journal=Essays Biochem. |volume=35 |issue=  |pages= 3-18 |year= 2003 |pmid= 12471886 |doi=  }}
* {{cite journal | vauthors = Leyva JA, Bianchet MA, Amzel LM | title = Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review) | journal = Molecular Membrane Biology | volume = 20 | issue = 1 | pages = 27–33 | year = 2003 | pmid = 12745923 | doi = 10.1080/0968768031000066532 }}
*{{cite journal | author=Oster G, Wang H |title=Rotary protein motors. |journal=Trends Cell Biol. |volume=13 |issue= 3 |pages= 114-21 |year= 2003 |pmid= 12628343 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Leyva JA, Bianchet MA, Amzel LM |title=Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review). |journal=Mol. Membr. Biol. |volume=20 |issue= 1 |pages= 27-33 |year= 2003 |pmid= 12745923 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Elston T, Wang H, Oster G | title = Energy transduction in ATP synthase | journal = Nature | volume = 391 | issue = 6666 | pages = 510–3 | date = Jan 1998 | pmid = 9461222 | doi = 10.1038/35185 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Wang H, Oster G | title = Energy transduction in the F1 motor of ATP synthase | journal = Nature | volume = 396 | issue = 6708 | pages = 279–82 | date = Nov 1998 | pmid = 9834036 | doi = 10.1038/24409 }}
*{{cite journal | author=Elston T, Wang H, Oster G |title=Energy transduction in ATP synthase. |journal=Nature |volume=391 |issue= 6666 |pages= 510-3 |year= 1998 |pmid= 9461222 |doi= 10.1038/35185 }}
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = Oct 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
*{{cite journal | author=Mao M, Fu G, Wu JS, ''et al.'' |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175-80 |year= 1998 |pmid= 9653160 |doi=  }}
* {{cite journal | vauthors = Bosetti F, Brizzi F, Barogi S, Mancuso M, Siciliano G, Tendi EA, Murri L, Rapoport SI, Solaini G | title = Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease | journal = Neurobiology of Aging | volume = 23 | issue = 3 | pages = 371–6 | year = 2002 | pmid = 11959398 | doi = 10.1016/S0197-4580(01)00314-1 }}
*{{cite journal  | author=Wang H, Oster G |title=Energy transduction in the F1 motor of ATP synthase. |journal=Nature |volume=396 |issue= 6708 |pages= 279-82 |year= 1998 |pmid= 9834036 |doi= 10.1038/24409 }}
* {{cite journal | vauthors = Cross RL | title = Molecular motors: turning the ATP motor | journal = Nature | volume = 427 | issue = 6973 | pages = 407–8 | date = Jan 2004 | pmid = 14749816 | doi = 10.1038/427407b }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Bosetti F, Brizzi F, Barogi S, ''et al.'' |title=Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. |journal=Neurobiol. Aging |volume=23 |issue= 3 |pages= 371-6 |year= 2002 |pmid= 11959398 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Cross RL |title=Molecular motors: turning the ATP motor. |journal=Nature |volume=427 |issue= 6973 |pages= 407-8 |year= 2004 |pmid= 14749816 |doi= 10.1038/427407b }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 13:52, 21 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The ATP5MF gene [1][2] encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

Function

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]

References

  1. ↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  2. ↑ 2.0 2.1 "Entrez Gene: ATP5MF ATP synthase membrane subunit f".

External links

Further reading


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