ATP5H: Difference between revisions
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The human [[gene]] ''' | The human [[gene]] '''ATP5PD''' encodes subunit d of the peripheral stalk part of the enzyme '''mitochondrial [[ATP synthase]]'''.<ref name="pmid11042152">{{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res | volume = 10 | issue = 10 | pages = 1546–60 |date=Nov 2000 | pmid = 11042152 | pmc = 310934 | doi =10.1101/gr.140200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP5PD ATP synthase peripheral stalk subunit d| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10476| accessdate = }}</ref> | ||
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| summary_text = [[Mitochondrion|Mitochondrial]] ATP synthase catalyzes [[Adenosine triphosphate|ATP]] synthesis, utilizing an electrochemical gradient of protons across the [[Inner mitochondrial membrane|inner membrane]] during [[oxidative phosphorylation]]. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F<sub>1</sub>, and the membrane-spanning component, F<sub>0</sub>, which comprises the [[Proton pump|proton channel]]. The F<sub>1</sub> complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F<sub> | | summary_text = [[Mitochondrion|Mitochondrial]] ATP synthase catalyzes [[Adenosine triphosphate|ATP]] synthesis, utilizing an electrochemical gradient of protons across the [[Inner mitochondrial membrane|inner membrane]] during [[oxidative phosphorylation]]. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F<sub>1</sub>, and the membrane-spanning component, F<sub>0</sub>, which comprises the [[Proton pump|proton channel]]. The F<sub>1</sub> complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F<sub>o</sub> seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F<sub>o</sub> complex. | ||
Alternatively [[RNA splicing|spliced]] [[Transcription (biology)|transcript]] variants encoding different [[isoform]]s have been identified for this gene. In addition, three [[pseudogene]]s are located on chromosomes [[Chromosome 9 (human)|9]], [[Chromosome 12 (human)|12]] and [[Chromosome 15 (human)|15]].<ref name="entrez"/> | Alternatively [[RNA splicing|spliced]] [[Transcription (biology)|transcript]] variants encoding different [[isoform]]s have been identified for this gene. In addition, three [[pseudogene]]s are located on chromosomes [[Chromosome 9 (human)|9]], [[Chromosome 12 (human)|12]] and [[Chromosome 15 (human)|15]].<ref name="entrez"/> | ||
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==External links== | ==External links== | ||
* {{UCSC gene info| | * {{UCSC gene info|ATP5PD}} | ||
==Further reading== | ==Further reading== | ||
Latest revision as of 13:44, 21 November 2018
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| ATP synthase D chain, mitochondrial | |||||||||
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| Symbol | ATP5H | ||||||||
| Pfam | PF05873 | ||||||||
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The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.[1][2]
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.[2]
References
- ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- ↑ 2.0 2.1 "Entrez Gene: ATP5PD ATP synthase peripheral stalk subunit d".
External links
- Human ATP5PD genome location and ATP5PD gene details page in the UCSC Genome Browser.
Further reading
- Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. PMID 12471886.
- Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
- Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923.
- Higuti T, Kuroiwa K, Miyazaki S, et al. (1994). "The complete amino acid sequence of subunit d of rat liver mitochondrial H(+)-ATP synthase". J. Biochem. 114 (5): 714–7. PMID 7509337.
- Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
- Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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