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ATP1A4 - Revision history
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WikiBot: Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
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<p>Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})</p>
<p><b>New page</b></p><div><!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --><br />
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{{GNF_Protein_box<br />
| image = <br />
| image_source = <br />
| PDB = <br />
| Name = ATPase, Na+/K+ transporting, alpha 4 polypeptide<br />
| HGNCid = 14073<br />
| Symbol = ATP1A4<br />
| AltSymbols =; ATP1A1; ATP1AL2; MGC25056<br />
| OMIM = 607321<br />
| ECnumber = <br />
| Homologene = 56958<br />
| MGIid = <br />
| GeneAtlas_image1 = PBB_GE_ATP1A4_gnf1h01969_at_tn.png<br />
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0005391 |text = sodium:potassium-exchanging ATPase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015077 |text = monovalent inorganic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015662 |text = ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} <br />
| Component = {{GNF_GO|id=GO:0005890 |text = sodium:potassium-exchanging ATPase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} <br />
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0015991 |text = ATP hydrolysis coupled proton transport}} {{GNF_GO|id=GO:0030317 |text = sperm motility}} {{GNF_GO|id=GO:0030641 |text = cellular hydrogen ion homeostasis}} <br />
| Orthologs = {{GNF_Ortholog_box<br />
| Hs_EntrezGene = 480<br />
| Hs_Ensembl = ENSG00000132681<br />
| Hs_RefseqProtein = NP_001001734<br />
| Hs_RefseqmRNA = NM_001001734<br />
| Hs_GenLoc_db = <br />
| Hs_GenLoc_chr = 1<br />
| Hs_GenLoc_start = 158387984<br />
| Hs_GenLoc_end = 158423391<br />
| Hs_Uniprot = Q13733<br />
| Mm_EntrezGene = <br />
| Mm_Ensembl = <br />
| Mm_RefseqmRNA = <br />
| Mm_RefseqProtein = <br />
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| Mm_GenLoc_chr = <br />
| Mm_GenLoc_start = <br />
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}}<br />
}}<br />
'''ATPase, Na+/K+ transporting, alpha 4 polypeptide''', also known as '''ATP1A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref><br />
<br />
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{{PBB_Summary<br />
| section_title = <br />
| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref><br />
}}<br />
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==References==<br />
{{reflist|2}}<br />
==Further reading==<br />
{{refbegin | 2}}<br />
{{PBB_Further_reading <br />
| citations = <br />
*{{cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na, K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37-89 |year= 1990 |pmid= 2158121 |doi= }}<br />
*{{cite journal | author=Buetow KH, Nishimura D, Nakamura Y, ''et al.'' |title=A detailed multipoint gene map of chromosome 1q. |journal=Genomics |volume=8 |issue= 1 |pages= 13-21 |year= 1991 |pmid= 1981991 |doi= }}<br />
*{{cite journal | author=Sverdlov ED, Broude NE, Sverdlov VE, ''et al.'' |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129-33 |year= 1987 |pmid= 2887455 |doi= }}<br />
*{{cite journal | author=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039-43 |year= 1987 |pmid= 3035563 |doi= }}<br />
*{{cite journal | author=Sverdlov ED, Monastyrskaya GS, Broude NE, ''et al.'' |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275-8 |year= 1987 |pmid= 3036582 |doi= }}<br />
*{{cite journal | author=Shamraj OI, Lingrel JB |title=A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12952-6 |year= 1995 |pmid= 7809153 |doi= }}<br />
*{{cite journal | author=Woo AL, James PF, Lingrel JB |title=Characterization of the fourth alpha isoform of the Na, K-ATPase. |journal=J. Membr. Biol. |volume=169 |issue= 1 |pages= 39-44 |year= 1999 |pmid= 10227850 |doi= }}<br />
*{{cite journal | author=Woo AL, James PF, Lingrel JB |title=Sperm motility is dependent on a unique isoform of the Na, K-ATPase. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20693-9 |year= 2000 |pmid= 10764792 |doi= 10.1074/jbc. M002323200 }}<br />
*{{cite journal | author=Woo AL, James PF, Lingrel JB |title=Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. |journal=Mol. Reprod. Dev. |volume=62 |issue= 3 |pages= 348-56 |year= 2003 |pmid= 12112599 |doi= 10.1002/mrd.90002 }}<br />
*{{cite journal | author=Keryanov S, Gardner KL |title=Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4. |journal=Gene |volume=292 |issue= 1-2 |pages= 151-66 |year= 2002 |pmid= 12119109 |doi= }}<br />
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}<br />
*{{cite journal | author=Lingrel J, Moseley A, Dostanic I, ''et al.'' |title=Functional roles of the alpha isoforms of the Na, K-ATPase. |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue= |pages= 354-9 |year= 2003 |pmid= 12763850 |doi= }}<br />
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}<br />
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}<br />
*{{cite journal | author=Hlivko JT, Chakraborty S, Hlivko TJ, ''et al.'' |title=The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm. |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 101-15 |year= 2006 |pmid= 16175638 |doi= 10.1002/mrd.20383 }}<br />
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}<br />
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}<br />
*{{cite journal | author=Rodova M, Nguyen AN, Blanco G |title=The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform. |journal=Mol. Reprod. Dev. |volume=73 |issue= 11 |pages= 1435-47 |year= 2006 |pmid= 16894555 |doi= 10.1002/mrd.20518 }}<br />
}}<br />
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