ATP1A4: Difference between revisions

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{{Infobox_gene}}
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'''Sodium/potassium-transporting ATPase subunit alpha-4''' is an [[enzyme]] that in humans is encoded by the ''ATP1A4'' [[gene]].<ref name="pmid1981991">{{cite journal | vauthors = Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC | title = A detailed multipoint gene map of chromosome 1q | journal = Genomics | volume = 8 | issue = 1 | pages = 13–21 |date=May 1991 | pmid = 1981991 | pmc =  | doi =10.1016/0888-7543(90)90220-O  }}</ref><ref name="pmid3035563">{{cite journal | vauthors = Shull MM, Lingrel JB | title = Multiple genes encode the human Na+,K+-ATPase catalytic subunit | journal = Proc Natl Acad Sci U S A | volume = 84 | issue = 12 | pages = 4039–43 |date=Jul 1987 | pmid = 3035563 | pmc = 305017 | doi =10.1073/pnas.84.12.4039 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = ATPase, Na+/K+ transporting, alpha 4 polypeptide
| HGNCid = 14073
| Symbol = ATP1A4
| AltSymbols =; ATP1A1; ATP1AL2; MGC25056
| OMIM = 607321
| ECnumber =
| Homologene = 56958
| MGIid =
| GeneAtlas_image1 = PBB_GE_ATP1A4_gnf1h01969_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0005391 |text = sodium:potassium-exchanging ATPase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015077 |text = monovalent inorganic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015662 |text = ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005890 |text = sodium:potassium-exchanging ATPase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0015991 |text = ATP hydrolysis coupled proton transport}} {{GNF_GO|id=GO:0030317 |text = sperm motility}} {{GNF_GO|id=GO:0030641 |text = cellular hydrogen ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 480
    | Hs_Ensembl = ENSG00000132681
    | Hs_RefseqProtein = NP_001001734
    | Hs_RefseqmRNA = NM_001001734
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 158387984
    | Hs_GenLoc_end = 158423391
    | Hs_Uniprot = Q13733
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
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    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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}}
'''ATPase, Na+/K+ transporting, alpha 4 polypeptide''', also known as '''ATP1A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref>


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-[[Co-transport|coupled transport]] of a variety of organic and inorganic molecules, and for [[electrical excitability]] of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ATP1A1}}
* {{UCSC gene info|ATP1A4}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na, K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue=  |pages= 37-89 |year= 1990 |pmid= 2158121 |doi= }}
*{{cite journal  | vauthors=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na, K-ATPase |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue=  |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=10.1016/S0079-6603(08)60708-4 | series=Progress in Nucleic Acid Research and Molecular Biology  | isbn=978-0-12-540038-1  }}
*{{cite journal | author=Buetow KH, Nishimura D, Nakamura Y, ''et al.'' |title=A detailed multipoint gene map of chromosome 1q. |journal=Genomics |volume=8 |issue= 1 |pages= 13-21 |year= 1991 |pmid= 1981991 |doi= }}
*{{cite journal  | vauthors=Sverdlov ED, Broude NE, Sverdlov VE |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=10.1016/0014-5793(87)80366-6 |display-authors=etal}}
*{{cite journal  | author=Sverdlov ED, Broude NE, Sverdlov VE, ''et al.'' |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129-33 |year= 1987 |pmid= 2887455 |doi= }}
*{{cite journal  | vauthors=Sverdlov ED, Monastyrskaya GS, Broude NE |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=10.1016/0014-5793(87)80677-4 |display-authors=etal}}
*{{cite journal | author=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039-43 |year= 1987 |pmid= 3035563 |doi=  }}
*{{cite journal  | vauthors=Shamraj OI, Lingrel JB |title=A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12952–6 |year= 1995 |pmid= 7809153 |doi=10.1073/pnas.91.26.12952  | pmc=45558 }}
*{{cite journal  | author=Sverdlov ED, Monastyrskaya GS, Broude NE, ''et al.'' |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275-8 |year= 1987 |pmid= 3036582 |doi=  }}
*{{cite journal  | vauthors=Woo AL, James PF, Lingrel JB |title=Characterization of the fourth alpha isoform of the Na, K-ATPase |journal=J. Membr. Biol. |volume=169 |issue= 1 |pages= 39–44 |year= 1999 |pmid= 10227850 |doi=10.1007/PL00005899 }}
*{{cite journal  | author=Shamraj OI, Lingrel JB |title=A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12952-6 |year= 1995 |pmid= 7809153 |doi=  }}
*{{cite journal  | vauthors=Woo AL, James PF, Lingrel JB |title=Sperm motility is dependent on a unique isoform of the Na, K-ATPase |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20693–9 |year= 2000 |pmid= 10764792 |doi= 10.1074/jbc.M002323200 }}
*{{cite journal  | author=Woo AL, James PF, Lingrel JB |title=Characterization of the fourth alpha isoform of the Na, K-ATPase. |journal=J. Membr. Biol. |volume=169 |issue= 1 |pages= 39-44 |year= 1999 |pmid= 10227850 |doi=  }}
*{{cite journal  | vauthors=Woo AL, James PF, Lingrel JB |title=Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility |journal=Mol. Reprod. Dev. |volume=62 |issue= 3 |pages= 348–56 |year= 2003 |pmid= 12112599 |doi= 10.1002/mrd.90002 }}
*{{cite journal  | author=Woo AL, James PF, Lingrel JB |title=Sperm motility is dependent on a unique isoform of the Na, K-ATPase. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20693-9 |year= 2000 |pmid= 10764792 |doi= 10.1074/jbc. M002323200 }}
*{{cite journal  | vauthors=Keryanov S, Gardner KL |title=Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4 |journal=Gene |volume=292 |issue= 1–2 |pages= 151–66 |year= 2002 |pmid= 12119109 |doi=10.1016/S0378-1119(02)00647-9 }}
*{{cite journal  | author=Woo AL, James PF, Lingrel JB |title=Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. |journal=Mol. Reprod. Dev. |volume=62 |issue= 3 |pages= 348-56 |year= 2003 |pmid= 12112599 |doi= 10.1002/mrd.90002 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Keryanov S, Gardner KL |title=Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4. |journal=Gene |volume=292 |issue= 1-2 |pages= 151-66 |year= 2002 |pmid= 12119109 |doi=  }}
*{{cite journal  | vauthors=Lingrel J, Moseley A, Dostanic I |title=Functional roles of the alpha isoforms of the Na, K-ATPase |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue=  |pages= 354–9 |year= 2003 |pmid= 12763850 |doi=10.1111/j.1749-6632.2003.tb07214.x |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Lingrel J, Moseley A, Dostanic I, ''et al.'' |title=Functional roles of the alpha isoforms of the Na, K-ATPase. |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue=  |pages= 354-9 |year= 2003 |pmid= 12763850 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Hlivko JT, Chakraborty S, Hlivko TJ |title=The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 101–15 |year= 2006 |pmid= 16175638 |doi= 10.1002/mrd.20383 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Hlivko JT, Chakraborty S, Hlivko TJ, ''et al.'' |title=The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm. |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 101-15 |year= 2006 |pmid= 16175638 |doi= 10.1002/mrd.20383 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Rodova M, Nguyen AN, Blanco G |title=The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform |journal=Mol. Reprod. Dev. |volume=73 |issue= 11 |pages= 1435–47 |year= 2006 |pmid= 16894555 |doi= 10.1002/mrd.20518 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Rodova M, Nguyen AN, Blanco G |title=The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform. |journal=Mol. Reprod. Dev. |volume=73 |issue= 11 |pages= 1435-47 |year= 2006 |pmid= 16894555 |doi= 10.1002/mrd.20518 }}
}}
}}
{{refend}}
{{refend}}


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{{ATPases}}
 
 
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Latest revision as of 18:24, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[1][2][3]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References

  1. ↑ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics. 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991.
  2. ↑ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
  3. ↑ 3.0 3.1 "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide".

External links

Further reading



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