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{{ | '''ATPase, H+/K+ transporting, nongastric, alpha polypeptide''' (also known as '''ATP12A''') is a [[protein]] that in humans is encoded by the ''ATP12A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=479| accessdate = }}</ref><ref name="pmid8838794">{{cite journal | vauthors = Sverdlov VE, Kostina MB, Modyanov NN | title = Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase | journal = Genomics | volume = 32 | issue = 3 | pages = 317–27 |date=March 1996 | pmid = 8838794 | doi = 10.1006/geno.1996.0125 | url = }}</ref><ref name="pmid2842249">{{cite journal | vauthors = Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U | title = Chromosomal localization of human Na<sup>+</sup>, K<sup>+</sup>-ATPase alpha- and beta-subunit genes | journal = Genomics | volume = 2 | issue = 2 | pages = 128–38 |date=February 1988 | pmid = 2842249 | doi = 10.1016/0888-7543(88)90094-8| url = http://linkinghub.elsevier.com/retrieve/pii/0888-7543(88)90094-8 }}</ref> | ||
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== Function == | |||
The protein encoded by this gene belongs to the family of [[P-type ATPase|P-type]] cation transport [[ATPase]]s. This gene encodes a catalytic subunit of the [[ouabain]]-sensitive H<sup>+</sup>/K<sup>+</sup> -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H<sup>+</sup> and K<sup>+</sup> ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.<ref name="entrez"/> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|ATP12A}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Modyanov NN, Petrukhin KE, Sverdlov VE |title=The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. |journal=FEBS Lett. |volume=278 |issue= 1 |pages= 91–4 |year= 1991 |pmid= 1847115 |doi=10.1016/0014-5793(91)80091-G |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Yang-Feng TL, Schneider JW, Lindgren V |title=Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. |journal=Genomics |volume=2 |issue= 2 |pages= 128–38 |year= 1988 |pmid= 2842249 |doi=10.1016/0888-7543(88)90094-8 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039–43 |year= 1987 |pmid= 3035563 |doi=10.1073/pnas.84.12.4039 | pmc=305017 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Sverdlov ED, Monastyrskaya GS, Broude NE |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=10.1016/0014-5793(87)80677-4 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN |title=Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 144–50 |year= 1994 |pmid= 8045293 |doi=10.1016/0014-5793(94)00655-5 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Sverdlov VE, Kostina MB, Modyanov NN |title=Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase. |journal=Genomics |volume=32 |issue= 3 |pages= 317–27 |year= 1997 |pmid= 8838794 |doi= 10.1006/geno.1996.0125 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Pestov NB, Romanova LG, Korneenko TV |title=Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. |journal=FEBS Lett. |volume=440 |issue= 3 |pages= 320–4 |year= 1999 |pmid= 9872395 |doi=10.1016/S0014-5793(98)01483-5 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Pestov NB, Korneenko TV, Adams G |title=Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization. |journal=Am. J. Physiol., Cell Physiol. |volume=282 |issue= 4 |pages= C907–16 |year= 2002 |pmid= 11880279 |doi= 10.1152/ajpcell.00258.2001 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Reinhardt J, Kosch M, Lerner M |title=Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 2 |pages= F335–43 |year= 2002 |pmid= 12110518 |doi= 10.1152/ajprenal.00226.2001 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Takahashi Y, Sakai H, Kuragari M |title=Expression of ATP1AL1, a non-gastric proton pump, in human colorectum. |journal=Jpn. J. Physiol. |volume=52 |issue= 3 |pages= 317–21 |year= 2003 |pmid= 12230809 |doi=10.2170/jjphysiol.52.317 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Li J, Codina J, Petroske E |title=The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function. |journal=Kidney Int. |volume=65 |issue= 4 |pages= 1301–10 |year= 2004 |pmid= 15086469 |doi= 10.1111/j.1523-1755.2004.00507.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Johansson M, Jansson T, Pestov NB, Powell TL |title=Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast. |journal=Placenta |volume=25 |issue= 6 |pages= 505–11 |year= 2004 |pmid= 15135233 |doi= 10.1016/j.placenta.2003.11.008 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
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ATPase, H+/K+ transporting, nongastric, alpha polypeptide (also known as ATP12A) is a protein that in humans is encoded by the ATP12A gene.[1][2][3]
Function
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".
- ↑ Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
- ↑ Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
External links
- Human ATP12A genome location and ATP12A gene details page in the UCSC Genome Browser.
Further reading
- Modyanov NN, Petrukhin KE, Sverdlov VE, et al. (1991). "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase". FEBS Lett. 278 (1): 91–4. doi:10.1016/0014-5793(91)80091-G. PMID 1847115.
- Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
- Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
- Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
- Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN (1994). "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family". FEBS Lett. 349 (1): 144–50. doi:10.1016/0014-5793(94)00655-5. PMID 8045293.
- Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Pestov NB, Romanova LG, Korneenko TV, et al. (1999). "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit". FEBS Lett. 440 (3): 320–4. doi:10.1016/S0014-5793(98)01483-5. PMID 9872395.
- Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization". Am. J. Physiol., Cell Physiol. 282 (4): C907–16. doi:10.1152/ajpcell.00258.2001. PMID 11880279.
- Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol. Renal Physiol. 283 (2): F335–43. doi:10.1152/ajprenal.00226.2001. PMID 12110518.
- Takahashi Y, Sakai H, Kuragari M, et al. (2003). "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum". Jpn. J. Physiol. 52 (3): 317–21. doi:10.2170/jjphysiol.52.317. PMID 12230809.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
- Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast". Placenta. 25 (6): 505–11. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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