ATOX1

ATX1 antioxidant protein 1 homolog (yeast)
PDB rendering based on 1fe0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fe0​, 1fe4​, 1fee​, 1tl4​, 1tl5​
Identifiers
Symbols	ATOX1 ; ATX1; HAH1; MGC138453; MGC138455
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2984
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ATX1 antioxidant protein 1 homolog (yeast), also known as ATOX1, is a human gene.

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

Further reading

• Klomp LW, Lin SJ, Yuan DS; et al. (1997). "Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis". J. Biol. Chem. 272 (14): 9221–6. PMID 9083055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hung IH, Casareno RL, Labesse G; et al. (1998). "HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense". J. Biol. Chem. 273 (3): 1749–54. PMID 9430722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Larin D, Mekios C, Das K; et al. (1999). "Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p". J. Biol. Chem. 274 (40): 28497–504. PMID 10497213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamza I, Schaefer M, Klomp LW, Gitlin JD (1999). "Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13363–8. PMID 10557326.CS1 maint: Multiple names: authors list (link)
• Wernimont AK, Huffman DL, Lamb AL; et al. (2000). "Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins". Nat. Struct. Biol. 7 (9): 766–71. doi:10.1038/78999. PMID 10966647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boultwood J, Strickson AJ, Jabs EW; et al. (2000). "Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene". Hum. Genet. 106 (1): 127–9. PMID 10982193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walker JM, Tsivkovskii R, Lutsenko S (2002). "Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity". J. Biol. Chem. 277 (31): 27953–9. doi:10.1074/jbc.M203845200. PMID 12029094.CS1 maint: Multiple names: authors list (link)
• Moore SD, Helmle KE, Prat LM, Cox DW (2003). "Tissue localization of the copper chaperone ATOX1 and its potential role in disease". Mamm. Genome. 13 (10): 563–8. doi:10.1007/s00335-002-2172-9. PMID 12420134.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu PC, Koeller DM, Kaler SG (2004). "Genomic organization of ATOX1, a human copper chaperone". BMC Genet. 4: 4. PMID 12594858.CS1 maint: Multiple names: authors list (link)
• Strausak D, Howie MK, Firth SD; et al. (2003). "Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein". J. Biol. Chem. 278 (23): 20821–7. doi:10.1074/jbc.M212437200. PMID 12679332.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ralle M, Lutsenko S, Blackburn NJ (2003). "X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines". J. Biol. Chem. 278 (25): 23163–70. doi:10.1074/jbc.M303474200. PMID 12686548.CS1 maint: Multiple names: authors list (link)
• Lutsenko S, Tsivkovskii R, Walker JM (2003). "Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1". Ann. N. Y. Acad. Sci. 986: 204–11. PMID 12763797.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wernimont AK, Yatsunyk LA, Rosenzweig AC (2004). "Binding of copper(I) by the Wilson disease protein and its copper chaperone". J. Biol. Chem. 279 (13): 12269–76. doi:10.1074/jbc.M311213200. PMID 14709553.CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anastassopoulou I, Banci L, Bertini I; et al. (2004). "Solution structure of the apo and copper(I)-loaded human metallochaperone HAH1". Biochemistry. 43 (41): 13046–53. doi:10.1021/bi0487591. PMID 15476398.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Banci L, Bertini I, Ciofi-Baffoni S; et al. (2005). "An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein". FEBS J. 272 (3): 865–71. doi:10.1111/j.1742-4658.2004.04526.x. PMID 15670166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jeney V, Itoh S, Wendt M; et al. (2005). "Role of antioxidant-1 in extracellular superoxide dismutase function and expression". Circ. Res. 96 (7): 723–9. doi:10.1161/01.RES.0000162001.57896.66. PMID 15761197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)