APLP1

Amyloid beta (A4) precursor-like protein 1
Identifiers
Symbols	APLP1 ; APLP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68447
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Amyloid beta (A4) precursor-like protein 1, also known as APLP1, is a human gene.

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Bayer TA, Cappai R, Masters CL; et al. (2000). "It all sticks together--the APP-related family of proteins and Alzheimer's disease". Mol. Psychiatry. 4 (6): 524–8. PMID 10578233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim TW, Wu K, Xu JL; et al. (1996). "Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density". Brain Res. Mol. Brain Res. 32 (1): 36–44. PMID 7494461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bush AI, Pettingell WH, de Paradis M; et al. (1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily". J. Biol. Chem. 269 (43): 26618–21. PMID 7929392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wasco W, Brook JD, Tanzi RE (1993). "The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19". Genomics. 15 (1): 237–9. doi:10.1006/geno.1993.1047. PMID 8432545.CS1 maint: Multiple names: authors list (link)
• Bressler SL, Gray MD, Sopher BL; et al. (1997). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Hum. Mol. Genet. 5 (10): 1589–98. PMID 8894693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paliga K, Peraus G, Kreger S; et al. (1998). "Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid". Eur. J. Biochem. 250 (2): 354–63. PMID 9428684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lenkkeri U, Kestilä M, Lamerdin J; et al. (1998). "Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1". Hum. Genet. 102 (2): 192–6. PMID 9521588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McNamara MJ, Ruff CT, Wasco W; et al. (1998). "Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains". Brain Res. 804 (1): 45–51. PMID 9729270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomita S, Ozaki T, Taru H; et al. (1999). "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein". J. Biol. Chem. 274 (4): 2243–54. PMID 9890987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Homayouni R, Rice DS, Sheldon M, Curran T (1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1". J. Neurosci. 19 (17): 7507–15. PMID 10460257.CS1 maint: Multiple names: authors list (link)
• Simons A, Ruppert T, Schmidt C; et al. (2002). "Evidence for a copper-binding superfamily of the amyloid precursor protein". Biochemistry. 41 (30): 9310–20. PMID 12135352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheinfeld MH, Ghersi E, Laky K; et al. (2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription". J. Biol. Chem. 277 (46): 44195–201. doi:10.1074/jbc.M208110200. PMID 12228233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walsh DM, Fadeeva JV, LaVoie MJ; et al. (2003). "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins". Biochemistry. 42 (22): 6664–73. doi:10.1021/bi027375c. PMID 12779321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamakami M, Yoshimori T, Yokosawa H (2004). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. PMID 14563850.CS1 maint: Multiple names: authors list (link)
• Adlerz L, Beckman M, Holback S; et al. (2004). "Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction". Brain Res. Mol. Brain Res. 119 (1): 62–72. PMID 14597230.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Q, Südhof TC (2004). "Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1". J. Biol. Chem. 279 (11): 10542–50. doi:10.1074/jbc.M310001200. PMID 14699153.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eggert S, Paliga K, Soba P; et al. (2004). "The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation". J. Biol. Chem. 279 (18): 18146–56. doi:10.1074/jbc.M311601200. PMID 14970212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)