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{{Infobox_gene}}
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'''Annexin A8-like protein 2''' is a [[protein]] that in humans is encoded by the ''ANXA8L2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANXA8 annexin A8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_ANXA8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1w3w.
| PDB = {{PDB2|1w3w}}, {{PDB2|1w45}}
| Name = Annexin A8
| HGNCid = 546
| Symbol = ANXA8
| AltSymbols =; ANX8; ANXA8L2; FLJ32754; VAC beta
| OMIM = 602396
| ECnumber = 
| Homologene = 88650
| MGIid = 
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005544 |text = calcium-dependent phospholipid binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 244
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001621
    | Hs_RefseqmRNA = NM_001630
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Annexin A8''', also known as '''ANXA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANXA8 annexin A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.<ref name="entrez">{{cite web | title = Entrez Gene: ANXA8 annexin A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=244| accessdate = }}</ref>
| summary_text = This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ANXA8}}
* {{UCSC gene info|ANXA8L1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gerke V, Moss SE |title=Annexins: from structure to function. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 331-71 |year= 2002 |pmid= 11917092 |doi= 10.1152/physrev.00030.2001 }}
*{{cite journal  |vauthors=Gerke V, Moss SE |title=Annexins: from structure to function. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 331–71 |year= 2002 |pmid= 11917092 |doi= 10.1152/physrev.00030.2001 }}
*{{cite journal  | author=Gerke V, Creutz CE, Moss SE |title=Annexins: linking Ca2+ signalling to membrane dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 449-61 |year= 2005 |pmid= 15928709 |doi= 10.1038/nrm1661 }}
*{{cite journal  |vauthors=Gerke V, Creutz CE, Moss SE |title=Annexins: linking Ca2+ signalling to membrane dynamics. |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 449–61 |year= 2005 |pmid= 15928709 |doi= 10.1038/nrm1661 }}
*{{cite journal  | author=Chang KS, Wang G, Freireich EJ, ''et al.'' |title=Specific expression of the annexin VIII gene in acute promyelocytic leukemia. |journal=Blood |volume=79 |issue= 7 |pages= 1802-10 |year= 1992 |pmid= 1313714 |doi=  }}
*{{cite journal  |vauthors=Chang KS, Wang G, Freireich EJ |title=Specific expression of the annexin VIII gene in acute promyelocytic leukemia. |journal=Blood |volume=79 |issue= 7 |pages= 1802–10 |year= 1992 |pmid= 1313714 |doi=  |display-authors=etal}}
*{{cite journal  | author=Chambers JA, Gardner E, Hauptmann R, ''et al.'' |title=TaqI polymorphisms at the annexin VIII locus (ANX8). |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 550 |year= 1993 |pmid= 1364010 |doi=  }}
*{{cite journal  |vauthors=Chambers JA, Gardner E, Hauptmann R |title=TaqI polymorphisms at the annexin VIII locus (ANX8). |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 550 |year= 1993 |pmid= 1364010 |doi=10.1093/hmg/1.7.550 |display-authors=etal}}
*{{cite journal  | author=Hauptmann R, Maurer-Fogy I, Krystek E, ''et al.'' |title=Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. |journal=Eur. J. Biochem. |volume=185 |issue= 1 |pages= 63-71 |year= 1989 |pmid= 2530088 |doi=  }}
*{{cite journal  |vauthors=Hauptmann R, Maurer-Fogy I, Krystek E |title=Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. |journal=Eur. J. Biochem. |volume=185 |issue= 1 |pages= 63–71 |year= 1989 |pmid= 2530088 |doi=10.1111/j.1432-1033.1989.tb15082.x |display-authors=etal}}
*{{cite journal  | author=Sarkar A, Yang P, Fan YH, ''et al.'' |title=Regulation of the expression of annexin VIII in acute promyelocytic leukemia. |journal=Blood |volume=84 |issue= 1 |pages= 279-86 |year= 1994 |pmid= 8018923 |doi=  }}
*{{cite journal  |vauthors=Sarkar A, Yang P, Fan YH |title=Regulation of the expression of annexin VIII in acute promyelocytic leukemia. |journal=Blood |volume=84 |issue= 1 |pages= 279–86 |year= 1994 |pmid= 8018923 |doi=  |display-authors=etal}}
*{{cite journal  | author=Reutelingsperger CP, van Heerde W, Hauptmann R, ''et al.'' |title=Differential tissue expression of Annexin VIII in human. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 120-4 |year= 1994 |pmid= 8045287 |doi=  }}
*{{cite journal  |vauthors=Reutelingsperger CP, van Heerde W, Hauptmann R |title=Differential tissue expression of Annexin VIII in human. |journal=FEBS Lett. |volume=349 |issue= 1 |pages= 120–4 |year= 1994 |pmid= 8045287 |doi=10.1016/0014-5793(94)00559-1 |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  |vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Stein T, Price KN, Morris JS, ''et al.'' |title=Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6872-9 |year= 2006 |pmid= 16203777 |doi= 10.1158/1078-0432.CCR-05-0547 }}
*{{cite journal  |vauthors=Stein T, Price KN, Morris JS |title=Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6872–9 |year= 2006 |pmid= 16203777 |doi= 10.1158/1078-0432.CCR-05-0547 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Goebeler V, Ruhe D, Gerke V, Rescher U |title=Annexin A8 displays unique phospholipid and F-actin binding properties. |journal=FEBS Lett. |volume=580 |issue= 10 |pages= 2430-4 |year= 2006 |pmid= 16638567 |doi= 10.1016/j.febslet.2006.03.076 }}
*{{cite journal  |vauthors=Goebeler V, Ruhe D, Gerke V, Rescher U |title=Annexin A8 displays unique phospholipid and F-actin binding properties. |journal=FEBS Lett. |volume=580 |issue= 10 |pages= 2430–4 |year= 2006 |pmid= 16638567 |doi= 10.1016/j.febslet.2006.03.076 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=244}}


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Revision as of 18:04, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.[1]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ANXA8 annexin A8".

External links

Further reading


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