AMG-1

AMG-1
	File:AMG-1.png
Identifiers
	IUPAC name (6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl- 6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol;
PubChem CID	10830874;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C23H30O2
Molar mass	338.482 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC=3CC1c2c(O)cc(C#CCCCCC)cc2OC(C)(C)C1CC=3;

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AMG-1 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a Ki of 0.6nM at CB₁ vs 3.1nM at CB₂.^[1]

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References

↑ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753

Template:WikiDoc Sources

[1] Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753

[1]

Identifiers
File:AMG-1.png
IUPAC name (6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl- 6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
PubChem CID	10830874
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₃H₃₀O₂
Molar mass	338.482 g/mol
3D model (JSmol)	Interactive image
SMILES CC=3CC1c2c(O)cc(C#CCCCCC)cc2OC(C)(C)C1CC=3

AMG-1

References

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