AKR1B10

Aldo-keto reductase family 1, member B10 (aldose reductase)
PDB rendering based on 1zua.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1zua​
Identifiers
Symbols	AKR1B10 ; ARL1; HIS; AKR1B11; AKR1B12; ALDRLn; ARL-1; HSI; MGC14103
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68934
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Aldo-keto reductase family 1, member B10 (aldose reductase), also known as AKR1B10, is a human gene.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Further reading

• Scuric Z, Stain SC, Anderson WF, Hwang JJ (1998). "New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma". Hepatology. 27 (4): 943–50. doi:10.1002/hep.510270408. PMID 9537432.CS1 maint: Multiple names: authors list (link)
• Cao D, Fan ST, Chung SS (1998). "Identification and characterization of a novel human aldose reductase-like gene". J. Biol. Chem. 273 (19): 11429–35. PMID 9565553.CS1 maint: Multiple names: authors list (link)
• Hyndman DJ, Flynn TG (1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochim. Biophys. Acta. 1399 (2–3): 198–202. PMID 9765596.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crosas B, Hyndman DJ, Gallego O; et al. (2003). "Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism". Biochem. J. 373 (Pt 3): 973–9. doi:10.1042/BJ20021818. PMID 12732097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petrovic MG, Peterlin B, Hawlina M, Petrovic D (2005). "Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians". J. Diabetes Complicat. 19 (2): 70–3. doi:10.1016/j.jdiacomp.2004.08.004. PMID 15745835.CS1 maint: Multiple names: authors list (link)
• Kang ES, Kim HJ, Paek KS; et al. (2005). "Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation". Cell. Mol. Life Sci. 62 (10): 1146–55. doi:10.1007/s00018-005-5024-4. PMID 15928807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee YS, Paek KS, Kang ES; et al. (2005). "Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells". Int. J. Biochem. Cell Biol. 37 (11): 2297–309. doi:10.1016/j.biocel.2005.04.016. PMID 15936242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vikramadithyan RK, Hu Y, Noh HL; et al. (2005). "Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice". J. Clin. Invest. 115 (9): 2434–43. doi:10.1172/JCI24819. PMID 16127462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hazemann I, Dauvergne MT, Blakeley MP; et al. (2005). "High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase". Acta Crystallogr. D Biol. Crystallogr. 61 (Pt 10): 1413–7. doi:10.1107/S0907444905024285. PMID 16204895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mashkova TD, Oparina NIu, Zinov'eva OL; et al. (2007). "[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer]". Mol. Biol. (Mosk.). 40 (6): 1047–54. PMID 17209433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tammali R, Ramana KV, Srivastava SK (2007). "Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells". Cancer Lett. 252 (2): 299–306. doi:10.1016/j.canlet.2007.01.001. PMID 17300864.CS1 maint: Multiple names: authors list (link)
• Yan R, Zu X, Ma J; et al. (2007). "Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention". Int. J. Cancer. 121 (10): 2301–6. doi:10.1002/ijc.22933. PMID 17597105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)